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Clinical Trials/DRKS00008943
DRKS00008943
Completed
未知

Obesity hypoventilation syndrome treated with non-invasive ventilation: can we switch to CPAP?

Pneumologie0 sites43 target enrollmentJuly 29, 2015
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ConditionsE66.2Extreme obesity with alveolar hypoventilation

Overview

Phase
未知
Intervention
Not specified
Conditions
E66.2
Sponsor
Pneumologie
Enrollment
43
Status
Completed
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
July 29, 2015
End Date
August 31, 2016
Last Updated
last year
Study Type
Interventional
Sex
All

Investigators

Eligibility Criteria

Inclusion Criteria

  • •Stable OHS patients on BiPAP therapy for at least 3 months considered successful as determined by diurnal PaCO2 \=45 mmHg and less than 20% of total sleep time with saturation \<90%.
  • •Initial OHS diagnosis before BiPAP implementation must fulfill the conventional diagnostic criteria: coexistence of obesity (BMI \=30 kg/m²) and daytime hypercapnia (PaCO2 \=45 mmHg) after excluding other hypoventilation conditions.
  • •Age \= 18 years

Exclusion Criteria

  • •FEV1/FVC% ratio \<70% plus FEV1 \<50%
  • •OHS patients on BiPAP therapy with unstable condition (\= 2 hospitalizations for acute respiratory failure in the last year)
  • •Daytime PaCO2 \= 45mmHg despite established BiPAP therapy
  • •Psychological incapacity to perform questionnaires
  • •Refusal to participate in the study

Outcomes

Primary Outcomes

Not specified

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