Pregnancy, Nitrate, Endothelial Function and Tissue Oxygen Saturation

Not Applicable

Completed

• Conditions: Pregnancy
• Interventions: Other: Beetroot juice; Other: Placebo

• Registration Number: NCT03315806
• Lead Sponsor: Universidade Federal do Rio de Janeiro

Brief Summary

Adequate macro and microvascular endothelial function during pregnancy is essential for the normal placental development and growing fetus. Beetroot juice (BJ) promotes improvement ins this parameters in no-pregnant individuals, however the beneficial effect did not avaliated in pregnant. The present study evaluated effects of BJ on macro and microvascular endothelial function in pregnant. Twelve pregnant were submitted to BJ and nitrate-depleted juice (PLA) interventions. Brachial flow-mediated dilation (FMD) and muscle oxygenation were measured 120 min after interventions. Urinary nitrate, nitrite were measured at baseline and 120 min after interventions.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-10-06
• Primary Completion: 2017-02-14
• Study Completion: 2017-05-19
• Study First Submitted: 2017-10-16
• Study First Submitted QC: 2017-10-16
• Study First Posted: 2017-10-20
• Status Verified: 2017-11
• Last Update Submitted: 2024-12-15
• Last Update Posted: 2024-12-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 12

Inclusion Criteria

• gestation between 20 and 35 weeks;
• over 18 years

Exclusion Criteria

• diabetes mellitus and gestational diabetes;
• hypertensive syndromes;
• HIV positive;
• liver or kidney disease;
• beetroot allergy;
• use of antioxidants and medicament that alter endothelial function;
• use of antibiotics up to 2 weeks before the visits and using.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Beetroot Juice	Beetroot juice	Beetroot juice containing 9 mmol of nitrate per dose
Placebo juice (nitrate depleted)	Placebo	Beetroot juice nitrate-depleted

Primary Outcome Measures

Name	Time	Method
Macro endothelial function	Evaluated 120 minutes after the nutritional intervention	Flow-mediated dilation (FMD)
Micro endothelial function	Evaluated 140 minutes after the nutritional intervention	Tissue oxygen saturation parameters
Nitrate urinary	Evaluated 150 minutes after the nutritional intervention