Effects of nutritional supplementation on nutritional status improvement in the convalescent rehabilitation ward

Not Applicable

• Conditions: Orthopedic patients, bone fracture patients

• Registration Number: JPRN-UMIN000038344
• Lead Sponsor: ational Center for Geriatrics and Gerontology

Brief Summary

Patients with musculoskeletal disease admitted to a rehabilitation ward received 6 g/day of Branched Chain Amino Acids in addition to exercise. Sarcopenia and nutrition status were assessed at admission, discharge, and one month after discharge. There were 42 subjects (mean age 80.3 years), the prevalence of sarcopenia was 36% at admission, 38% discharge and 18% one month after discharge, and low nutrition was 55% at admission, 51% discharge and 42% one month after discharge.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-10-21
• Results First Posted: 2021-01-27
• Study Completion: 2021-12-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

Not provided

Exclusion Criteria

Motor paralysis and higher brain dysfunction due to cerebrovascular disease Physically and mentally severe condition due to malignant tumors and severe dementia Bedridden at the end of the disease Peripheral vascular disease with intermittent claudication Acute arthritis Severe chronic obstructive pulmonary disease heart failure (New York Heart Association (NYHA) stage 3 or 4) specific myopathy Bio impedance Analysis (BIA) contraindications (Ex. Cardiac pacemaker) Kidney disease (CKD stage3 or higher) Milk component allergy Moderate or higher obesity (BMI>=30) Uncontrolled diabetes mellitus

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Alb(Serum albumin)

Secondary Outcome Measures

Name	Time	Method
Basic information: body mass index (BMI), medical history, need of care, family living together, exercise habits, smoking and drinking history, falls experience Muscle mass: Bio impedance Analysis method (BIA) using Inbody S10 Blood data: TLC, T-CHO, TP, CRP, Hb, Cre Mini Nutritional Assessment (MNA) International standards for undernutrition (GLIM criteria; 2018) Kihon Check List (KCL) Physical function: walking speed, Timed Up and Go test (TUG), One leg standing, Knee extension strength, Grip strength Physical activity evaluation; 3-axis accelerometer Lifecoder GS (manufactured by Suzuken) FIM (Functional Independent Measures) Mini-Mental State Examination (MMSE) Geriatric Depression Scale (GDS)