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临床试验/CTRI/2025/01/079280
CTRI/2025/01/079280尚未招募4 期

Comparison of two doses of dexmedetomidine as adjuvants in external oblique intercostal block (EOIB) on postoperative analgesia in laparoscopic upper abdominal surgeries. a double blinded randomised controlled trial

All India Institute of Medical Sciences1 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2025年2月5日最近更新:

试验速览

阶段
4 期
状态
尚未招募
入组人数
80
试验地点
1
主要终点
Fentanyl consumption

研究概览

简要总结

Upper abdominal surgeries are associated with severe pain. Neuraxial blocks are gold standard but are not feasible in all patients. External oblique intercostaal block (EOIB) provides analgesia from T6-T10 dermatomes. It is easy to administer, even in obese patients, injection is away from surgical field. Previous literature on this block exists in the form of case series, reports and a single randomised study on laparoscopic cholecystectomy. Dexmedetomidine acts as an adjuvant improves the analgesic efficacy of perineural blocks.  No previous studies have used dexmedetomidine in external oblique intercostal block.

We therefore aim to assess the analgesic efficacy of two doses of dexmedetomidine as adjuvant to external oblique intercostal block in laparoscopic surgeries.

Both intervention and control groups in this sstudy will be provided adequate intraoperative analgesia using fentanyl boluses and postoperative analgesia using fentanyl iv patient controlled analgesia (PCA). Total consumption of fentanyl will be noted for both groups at 24 hours postoperatively.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
Participant, Investigator and Outcome Assessor Blinded

入排标准

年龄范围
18.00 Year(s) 至 70.00 Year(s)(—)
性别
All

入选标准

  • a) Age 18 to 70 years old b) American Society of Anesthesiology (ASA ) class 1 and 2 c) Patients undergoing laparoscopic upper abdominal surgeries.

排除标准

  • a) Patients who deny consent b) Presence of local infection c) Local anaesthetic allergy.

结局指标

主要结局

Fentanyl consumption

时间窗: Fentanyl consumption at 24 hours postoperatively

次要结局

  • 1. Pain score as measured by numerical rating scale(2. Postoperative nausea vomiting)

研究者

申办方类型
Research institution
责任方
Principal Investigator
主要研究者

Dr Aditi Suri

All India Institute of Medical Sciences

研究点 (1)

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