Smell and Taste Dysfunction in Children with Cancer
- Conditions
- Childhood cancer patients
- Registration Number
- NL-OMON25750
- Lead Sponsor
- Princess Máxima Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion criteria patients:
-Children, 6-17 years old
-Currently undergoing chemotherapy
Inclusion criteria controls (siblings):
-Children, 6-17 years old
Exclusion criteria patients:
-Children with isolated congenital anosmia (ICA; a complete loss of smell)
-Children = 5 years
-Children and parents that do not understand the Dutch language
-Children with a self-reported allergy to quinine
-Children with severe oral mucositis (treatment-induced ulceration of the mucosa, blis-tered tongue, and absence of saliva)
Exclusion criteria controls:
-Children with isolated congenital anosmia (ICA; a complete loss of smell)
-Children = 5 years
-Children and parents that do not understand the Dutch language
-Children with a self-reported allergy to quinine
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The main study parameter is feasibility of the study. Therefore we will test whether the lower age range is suitable to be tested. If not, for our next studies we will increase the lower age limit. The number of patients fully completing the study is the main endpoint.
- Secondary Outcome Measures
Name Time Method -Smell function<br>-Taste function<br>-Subjective smell and taste function (questionnaire) <br>-Papillae density <br>- Eating behaviour