Human thermoregulatory behavior and thermo-physiology before and after mild heat acclimation in healthy lean and obese subjects - Thermoregulatory behaviour and mild heat acclimation

niversiteit Maastricht0 个研究点目标入组 48 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

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•Caucasian healthy lean volunteers
•* Generally healthy
•* male or female
•* Age: 18 to 35 years
•* BMI: 20-25 kg/m2
•* Women using Microgynon 30 or levonorgestrel/ehinylestradiol;Inclusion criteria obese vrijwilligers
•* Generally healthy
•* male or female
•* Age 18 to 35 years
•* BMI 28-35 kg/m2
•* Women using Microgynon 30 or levonorgestrel/ethinylestradiol

•* Participants that do not want to be informed about accidental medical findings, which might occur during the study.
•o If participants do not want us to inform their general practitioners about unexpected medical findings, they cannot participate in the study.;* Participate in physical activity more than 2x/week
•o We will exclude individuals that participate in endurance sports (like swimming, running, cycling) more than two hours per week. Endurance-trained athletes seem to have differing thermo-physiology, which has, amongst others, been recently confirmed by another study of our laboratory (Vosselman et al, submitted).
•* Participation in another biomedical study within 1 month before the first screening visit
•* Diabetes mellitus type I and II
•* Pregnancy
•* Unstable weight (weight gain or loss > 5 kg in the last three months)
•* Hypertension (systolic/diastolic blood pressure >140/90)
•* Hypotension (systolic/diastolic blood pressure <90/60)
•* General feeling of illness at day of experiment
•* (History of) cardiovascular diseases
•* Contraindications for the telemetric pill:
•o In the presence of any known or suspected obstructive disease of the gastrointestinal tract, including but not limited to diverticulitis and inflammatory bowel disease
•o A history of disorders or impairment of the gag reflex
•o Previous gastrointestinal surgery
•o Hypo motility disorders of the gastrointestinal tract including but not limited to Illeus

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