Relationship Between Ocular Pulse Amplitude And Choroidal Laser Doppler Flowmetry In Healthy Subjects
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- An association of OPA with the LDF pulsatility index
研究概览
简要总结
This study intends to investigate the relationship between choroidal blood flow and ocular pulse amplitude (OPA).
详细描述
One eye is randomly selected in 18 healthy subjects. OPA is assessed with Dynamic Contour Tonometry. Submacular choroidal blood flow is measured with Laser Doppler Flowmetry. During both examinations the systemic blood pressure is continuously recorded with Finometer. An average systolic and diastolic LDF parameter flow during 30 seconds are determined and the pulsatility index is calculated according to the formula (LDFsys-LDFdia)/LDFdia. An association of OPA with the LDF pulsatility index, systemic blood pressure values and mean intraocular pressure will be analysed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects should present no history of ocular diseases, of current topical medication, or of drug or alcohol abuse. Furthermore, a best corrected visual acuity above 20/25 in both eyes, lack of pathological findings upon a slit-lamp examination and dilated direct fundoscopy, and an IOP < 21 mmHg in both eyes will be required.
排除标准
- •History of chronic or recurrent severe inflammatory eye disease such as scleritis or uveitis.
- •History of ocular trauma or intraocular surgery. History of infection or inflammation within the past 3 months.
- •History and clinical evidence for other retinal disease such as age-related degeneration, or diabetic retinopathy.
结局指标
主要结局
An association of OPA with the LDF pulsatility index
时间窗: 30 seconds
次要结局
- An association of OPA with the systemic blood pressure values(30 seconds)
- An association of OPA with mean intraocular pressure(30 seconds)