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Clinical Trials/NCT02261233
NCT02261233
Terminated
N/A

Osteopathic Manipulative Treatment and Postural Control: Systems Engineering Approach

Michigan State University3 sites in 1 country63 target enrollmentApril 1, 2014
ConditionsLow Back Pain

Overview

Phase
N/A
Intervention
Not specified
Conditions
Low Back Pain
Sponsor
Michigan State University
Enrollment
63
Locations
3
Primary Endpoint
Change in postural control
Status
Terminated
Last Updated
7 years ago

Overview

Brief Summary

The overall goal of this project is to develop sensitive and objective clinical research tools for the assessment of postural control of the trunk. In order to accomplish this goal, we aim to quantify balance performance in an unstable seated task. Specifically, the investigators will quantify balance performance in low back pain participants before and after osteopathic manipulative treatment. The investigators hypothesize that there will be a significant improvement in balance performance after a single session of osteopathic manipulative treatment as well as after 4 sessions of osteopathic manipulative treatment and this improvement will be greater than any learning effect.

A secondary objective of this study is to quantify differences in patient-oriented outcome measures (e.g., self-reported pain, disability) in low back pain participants before and after osteopathic manipulative treatment. The investigators hypothesize that there will be a significant improvement in these self-reported outcomes following osteopathic manipulative treatment. The association between improvement in postural control parameters and patient-oriented measures will also be explored.

Registry
clinicaltrials.gov
Start Date
April 1, 2014
End Date
August 31, 2018
Last Updated
7 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Jacek Cholewicki

Walter F. Patenge Professor

Michigan State University

Eligibility Criteria

Inclusion Criteria

  • All participants must meet all of the inclusion criteria to participate in the study. Below is a list of inclusion criteria for LBP participants:
  • Age 21-65 years
  • Independently ambulatory
  • Able to speak and read English
  • Able to understand study procedures and to comply with them for the entire length of the study.
  • Willing to be randomized to either immediate or delayed treatment group.
  • Musculoskeletal pain - primarily in the low back region
  • Pain rating equal to or greater than 3 out of10 as indicated on the Numeric Rating Scale for Pain
  • Disability equal to or greater than 26% as indicated on the Oswestry Disability Questionnaire

Exclusion Criteria

  • All candidates meeting any of the exclusion criteria at baseline will be excluded from study participation. Exclusion criteria will be self-reported. However, during each treatment session, the physicians will be watching for clinical signs and symptoms not consistent with physical findings that are suggestive of the presence of any of the exclusion criteria. In such a case, further treatment will be discontinued and the subject will be excluded.
  • Below is a list of exclusion criteria:
  • Inability or unwillingness of individual to give written informed consent.
  • Physical therapy or any other form of manual medicine (e.g., Osteopathic Manipulative Medicine, Chiropractic Manipulation, etc.), acupuncture or spinal injections within one month prior to study enrollment
  • Workers' compensation benefits in the past 3 months or ongoing medical legal issues
  • Possibly pregnant
  • Obesity (BMI\>32)
  • Currently using electrical implants (e.g., cardiac pacemakers, drug delivery pumps, etc.)
  • History of:
  • Spinal surgery

Outcomes

Primary Outcomes

Change in postural control

Time Frame: Change from baseline to shortly after first treatment (1-2 days), from baseline to an expected average of week 4, and from week 4 to an expected average of week 8.

Postural control will be assessed in an unstable seated task, in which subjects will be asked to balance on a specially designed seat. The average deviations from the neutral seat position will be measured in degrees.

Change in trunk muscle reflex latency

Time Frame: Change from baseline to shortly after first treatment (1-2 days), from baseline to an expected average of week 4, and from week 4 to an expected average of week 8.

Subjects will be pulling with their trunk on a cable held by an electromagnet. The electromagnet will be suddenly released. Trunk muscle response to sudden load release will be measured on electromyographical recordings in milliseconds.

Secondary Outcomes

  • Change in Oswestry Disability Index(The expected average is weekly for this outcome measure until the end (expected average of 8 weeks).)
  • Change in Patient Reported Outcomes Measurement Information System (PROMIS)(The expected average is weekly for this outcome measure until the end (expected average of 8 weeks).)
  • Change in concomitant medication(The expected average is weekly for this outcome measure until the end (expected average of 8 weeks).tcome measure until the end, an expected average of 8 weeks.)
  • Change in fear avoidance behavior(The expected average is weekly for this outcome measure until the end (expected average of 8 weeks).)

Study Sites (3)

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