Assessment Of Lipid Profile In Cirrhotic Patients And Its Relation To The Disease Severity.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Sohag University
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Measurement of the lipid profile in cirrhotic patients and compare its levels with normal persons.
Study Overview
Brief Summary
Cirrhosis is defined anatomically as a diffuse process with fibrosis and nodule formation. It is the result of the fibrogenesis that occurs with chronic liver injury.
Lipoproteins are complexes of lipid and proteins that are essential for transport of soluble vitamins Liver cells play a serious task in the regulation of lipid metabolism. The principal location for lipoprotein and cholesterol synthesis is in the liver.
In healthy individuals, a compound equilibrium is preserved between utilization, biosynthesis, and transfer of lipid fractions.
Many diseases that affect the parenchyma can lead to changes in the structure of lipoproteins and transport throughout the blood.
Nevertheless, in cirrhotic patients, the metabolism of lipid is changed such that glycogen stores are significantly diminished, contributing to malnutrition and biolysis.
Detailed Description
Cirrhosis is defined anatomically as a diffuse process with fibrosis and nodule formation. It is the result of the fibrogenesis that occurs with chronic liver injury.
Lipoproteins are complexes of lipid and proteins that are essential for transport of soluble vitamins Liver cells play a serious task in the regulation of lipid metabolism. The principal location for lipoprotein and cholesterol synthesis is in the liver.
In healthy individuals, a compound equilibrium is preserved between utilization, biosynthesis, and transfer of lipid fractions.
Many diseases that affect the parenchyma can lead to changes in the structure of lipoproteins and transport throughout the blood.
Nevertheless, in cirrhotic patients, the metabolism of lipid is changed such that glycogen stores are significantly diminished, contributing to malnutrition and biolysis.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Cirrhotic patients .
Exclusion Criteria
- •1-Patients with diabetes mellitus,malignancy,uremia. 2-Patients with history of drugs for dyslipidemia. 3- Patients presented with hepatocellular carcinoma 4- Wilsons disease. 5-Rheumatoid arthritis. 6- Systemic lupus.
Outcomes
Primary Outcomes
Measurement of the lipid profile in cirrhotic patients and compare its levels with normal persons.
Time Frame: 15 weeks from start point.
Via measurement the levels of triglyceride (TG), total cholesterol,very low-density lipoprotein, low density lipoprotien (LDH), and high-density lipoprotien (HDL) in cirrhotic patients and compare with the control.
Secondary Outcomes
- Measurement the degree of liver cirrhosis severity and its relationship to lipid profile levels.(15 weeks from start point)
Investigators
manal mostafa kamel
Resident in Tropical Medicine and Gastroenterology Department
Sohag University