Biomarkers in Dyspnea
- Conditions
- Healthy Volunteers
- Interventions
- Other: Induced dyspnea
- Registration Number
- NCT03056547
- Lead Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
- Brief Summary
To explore biological mechanisms in human model of induced dyspnea, in order to remove the source of dyspnoea, to modify cerebral impact and to allow the development of targeted therapies.
- Detailed Description
The aim of the study will be to identify a specific biology and immunology associated with dyspnoea. It will open therapeutic possibilities through a better understanding of the mechanisms of dyspnea.
Healthy volunteers will underwent two types of dyspnea. The subjects will be first familiar with both types of dyspnea and dyspnea measurement scales. Different components of dyspnea will be measured.
Blood tests will be performed at different times (before dyspnea, during dyspnea, 60 and 90 min after dyspnea)
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 34
- healthy volunteers
- pregnancy
- ongoing pain
- respiratory disease
- high levels of depression, panic disorder, or other significant mental health problems
- not fluent in french
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Induced dyspnea Induced dyspnea -
- Primary Outcome Measures
Name Time Method Biomakers in dyspnea 60 minutes Biomarkers in human model of induced dyspnea
- Secondary Outcome Measures
Name Time Method Correlation with dyspnea intensity 60 minutes Correlation between intensity of dyspnea and biomarkers
Correlation with dyspnea type 60 minutes Correlation between type of dyspnea and biomarkers
Trial Locations
- Locations (1)
Centre d'Investigation Clinique Paris Est - Groupe Hospitalier Pitié-Salpêtrière
🇫🇷Paris, France