Genetic Polymorphisms of Interleukin-1B and TNF-A and HBV-Related Hepatocellular Carcinoma
- Conditions
- Hepatitis BHepatocellular CarcinomaChronic Liver Disease
- Interventions
- Genetic: Polymorphism of IL-1 beta and TNF-alpha
- Registration Number
- NCT00629486
- Brief Summary
By detecting polymorphisms of IL-1β and TNF-α,this study aims to find the effects of cytokine gene polymorphisms(and their interaction) on susceptibility and severity of HBV-related HCC.
- Detailed Description
Hepatitis B virus (HBV)infection is the major risk factor for chronic liver disease and hepatocellular carcinoma (HCC). Host immunogenetic factors contribute to HBV-associated liver damage and/or carcinogenesis. Variant cytokine alleles, including tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β), might contribute to interindividual difference in inflammatory responses and account for heterogeneous disease outcome of infectious disease.
By detecting polymorphisms of IL-1β and TNF-α,this study aims to find the effects of cytokine gene polymorphisms(and their interaction) on susceptibility and severity of HBV-related HCC.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 300
- HBsAg-positive patients
- HBsAg-negative patients
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description cytokines were determined Polymorphism of IL-1 beta and TNF-alpha prevalence of genetic polymorphisms of interleukin 1B was measured in HBV-related hepatocellular carcinoma
- Primary Outcome Measures
Name Time Method cytokine polymorphisms increase risk for hepatocellular carcinoma years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan
Kaohsiung Medical University Chung-Ho Hospital
🇨🇳Kaohsiung, Taiwan