CTRI/2018/07/015002招募中2 期
A randomised trial of prednisolone and methotrexate Vs prednisolone alone to assess the adjuvant potential of methotrexate in mucosal/ limited mucocutaneous pemphigus vulgaris
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- PGIMER
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1. Patients of pemphigus vulgaris with oral mucosal lesions with no cutaneous involve- ment or limited cutaneous involvement (i.e. less than 5% BSA)
- •2. Attending the immunobullous disease clinic of the Department of Dermatology for the first time
- •3. Age more than 18 years.
- •4. Willing for biweekly follow up for 1 month & monthly follow up visits for atleast 8 months thereafter
排除标准
- •1. Individuals upto 18 years of age
- •2. Inability to come for follow up till 9 months
- •3. Pregnant and lactating females
- •4. Elderly patients aged 70 years or older for practical difficulty in following up or unre- liable patients
- •5. Significant anaemia, leukopenia or thrombocytopenia
- •6. Chronic infection or immunosuppressed state (e.g TB, HIV)
- •7. Heavy alcohol consumption or hepatic impairment
- •8. Renal insufficiency
- •9. History suggestive of allergy to methotrexate
- •10. Planning to start a family in next 12 months or not willing for contraception
研究者
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