The Efficiency and Safety of Fibreoptic Bronchoscopy Assisted Intubation During Noninvasive Positive Pressure Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 106
- 试验地点
- 1
- 主要终点
- Change in pulse oxymetry(SpO2)
研究概览
简要总结
This study is to investigate the efficiency and safety of fibreoptic bronchoscopy assisted intubation during noninvasive positive pressure ventilation in respiratory failure patients. Half of the participants will receive preoxygenation with noninvasive ventilator and fibreoptic bronchoscopy intubation during NIPPV. While the other half using usual preoxygenation(bag-mask ventilation ).
详细描述
Respiratory failure is very common for critically ill patients, Main complication associated with intubation was desaturation. Usual preoxygenation( bag-mask ventilation) have been show that marginally effective in critically ill patients. As a result, there is a need to optimize the technique of preoxygenation to prolong the safe duration of apnea during the intubation procedure in critically ill patients. Noninvasive ventilation provides continuous positive airway pressure is effective in increasing the efficiency of gas exchange and in reducing the decrease in oxyhemoglobin saturation during fiberoptic bronchoscopy in hypoxemic patients.
Therefore, our aim was to study whether NIPPV is more effective at reducing desaturation than usual preoxygenation in hypoxemic, critically ill patients requiring intubation in ICU.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute respiratory failure requiring intubation,
- •Age greater than or equal to 18 years
排除标准
- •Nasal polyps，Nasopharyngeal cancer，Nasal bleeding，Rhinitis，Sinusitis and so on Nasal disease
- •Basal skull fracture
- •Severe coagulopathy, blood platelet counts <50×10*9/L
- •Nose and facial deformities, trauma
- •Cardiac arrest
- •Pregnancy or puerpera
研究组 & 干预措施
Control
Preoxygenation with Bag-mask ventilation before fibreoptic bronchoscopy assisted intubation.
Intervention: Bag-mask ventilation.
干预措施: Bag-mask ventilation (Procedure)
Control
Preoxygenation with Bag-mask ventilation before fibreoptic bronchoscopy assisted intubation.
Intervention: Bag-mask ventilation.
干预措施: fibreoptic bronchoscopy assisted intubation (Procedure)
NIPPV
The NIPPV group preoxygenation with noninvasive positive pressure ventilation(NIPPV), And then receives fibreoptic bronchoscopy intubation through a face mask (there is a small hole allow to insert the tracheal tube through the mask into trachea) during NIPPV.
Intervention: noninvasive positive pressure ventilation(NIPPV)
干预措施: Noninvasive positive pressure ventilation(NIPPV) (Procedure)
NIPPV
The NIPPV group preoxygenation with noninvasive positive pressure ventilation(NIPPV), And then receives fibreoptic bronchoscopy intubation through a face mask (there is a small hole allow to insert the tracheal tube through the mask into trachea) during NIPPV.
Intervention: noninvasive positive pressure ventilation(NIPPV)
干预措施: fibreoptic bronchoscopy assisted intubation (Procedure)
结局指标
主要结局
Change in pulse oxymetry(SpO2)
时间窗: From time of randomization until connect to ventilator 30min
次要结局
- Mechanical ventilation Time(28 days)
研究者
Lingbo Nong
MD
The First Affiliated Hospital of Guangzhou Medical University