Endothelial Cell Gene Networks of CVD
- Conditions
- Coronary Heart Disease
- Interventions
- Other: isolation of endothelial cells precursors in blood
- Registration Number
- NCT03529916
- Lead Sponsor
- Tufts University
- Brief Summary
The objective of this study is to identify relevant signature gene networks of cardiovascular disease in endothelial cells derived from circulating endothelial progenitor cells of individuals with established cardiovascular disease (CVD).
- Detailed Description
The investigators propose to enroll CVD and healthy subjects between 30 and 60 years of age, matched for age, gender, body mass index, and medication (statin and anti-hypertensive) use. Circulating endothelial progenitor cells will be isolated from blood and cultured in vitro to differentiate into endothelial cells.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description CVD subjects isolation of endothelial cells precursors in blood CVD will be defined as \>50% stenosis of one or more coronary arteries as assessed by coronary angiography. healthy controls isolation of endothelial cells precursors in blood healthy controls defined as not having stenosis of coronary arteries as assessed by coronary angiography.
- Primary Outcome Measures
Name Time Method Gene expression 10 weeks Gene expression \[ identify relevant signature gene networks of cardiovascular disease in endothelial cells\]
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Tufts Medical Center - Cardiovascular Clinic
🇺🇸Boston, Massachusetts, United States