Endothelial Cell Gene Networks of CVD
Trial Snapshot
- Phase
- Not Applicable
- Status
- Withdrawn
- Sponsor
- Tufts University
- Locations
- 1
- Primary Endpoint
- Gene expression
Study Overview
Brief Summary
The objective of this study is to identify relevant signature gene networks of cardiovascular disease in endothelial cells derived from circulating endothelial progenitor cells of individuals with established cardiovascular disease (CVD).
Detailed Description
The investigators propose to enroll CVD and healthy subjects between 30 and 60 years of age, matched for age, gender, body mass index, and medication (statin and anti-hypertensive) use. Circulating endothelial progenitor cells will be isolated from blood and cultured in vitro to differentiate into endothelial cells.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 30 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Gene expression
Time Frame: 10 weeks
Gene expression \[ identify relevant signature gene networks of cardiovascular disease in endothelial cells\]
Secondary Outcomes
No secondary outcomes reported
Investigators
Stefania lamon-Fava
Scientist I, Associate Professor
Tufts University