The Impact of Short-Chain Fatty Acids on the Gut Hormone Release After Delivery in the Small Intestine and Colon
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- KU Leuven
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- The release of gut hormones
研究概览
简要总结
The goal of this crossover study is to evaluate the impact of short-chain fatty acids (SCFA) on the gut hormone release after administration in the small intestine or colon in healthy participants. The main question it aims to answer is whether the site of administration of SCFA affects the gut hormone release. On test days participants will ingest capsules filled with SCFA that are specifically delivered in the small intestine or the colon. Subsequently, blood samples are collected at regular time points.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •male and female
- •normal BMI (18.5-25 kg/m^2)
- •age within 18-50 years
排除标准
- •Chronic gastrointestinal disorders such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), celiac disease, chronic constipation (less than 3 stools a week) and chronic frequent diarrhoea (more than 3 stools a day)
- •Previous abdominal surgery, except from appendectomy
- •Being on a weight loss, gluten-free, lactose-free, or vegan diet
- •The donation of blood during the last 3 months or suffering from low blood haemoglobin levels
- •The use of antibiotics or other medication that affects the gastrointestinal tract 3 months preceding the study and/or during the study
- •The use of prebiotics or probiotics 2 weeks preceding the study and/or during the study
- •Pregnancy, lactation or wish to become pregnant during the study period
- •Previous or current substance/alcohol dependence or abuse (> 2 units per day/14 units per week)
研究组 & 干预措施
Colon-delivery capsules
SCFA
干预措施: SCFA (Dietary Supplement)
Small intestinal delivery capsules
SCFA
干预措施: SCFA (Dietary Supplement)
placebo capsules
Microcristalline cellulose
干预措施: microcristalline cellulose (Dietary Supplement)
结局指标
主要结局
The release of gut hormones
时间窗: 8 hours
Gut hormone GLP-1 (pmol/l) and PYY (pg/ml) concentrations will be quantified in the blood samples collected at different time points.
次要结局
- The glycemic and insulinemic response(8 hours)