NCT05969834已完成不适用
Human Chorionic Gonadotropin Levels After Ovulation Triggering as Predictors of Intracytoplasmic Sperm Injection Outcome
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Clinical pregnancy rate
研究概览
简要总结
This study aimed to assess the correlation between HCG levels after ovulation triggering and ICSI outcomes, affected by HCG formulation and dose
详细描述
The aims of this study are:
- To assess the correlation between serum human chorionic gonadotropin (hCG) level after ovulation triggering and intracytoplasmic sperm injection (ICSI) outcome including: oocyte maturity and quality, good quality embryo rate, blastocyst formation rate and pregnancy rate
- To determine if there is an association between type and dose of the trigger and ICSI outcome.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women who will undergo controlled ovarian stimulation (COS) through fixed GnRH antagonist protocol
排除标准
- •BMI > 30 kg/m2
- •Irregular menstruation
- •Severe male factor abnormality
- •Poor ovarian reserve
- •Endometriosis
- •Uterine abnormality
研究组 & 干预措施
uHCG group
Trigger intramuscular (IM) administration of 10000 IU of uHCG
干预措施: uHCG (Drug)
rHCG group
Trigger with subcutaneous (SC) administration of 6500 IU of rHCG
干预措施: rHCG (Drug)
Dual trigger group
Combined SC administration of 0.1 mg of GnRHa and IM administration of 2500 IU of uHCG
干预措施: uHCG and GnRHa (Drug)
结局指标
主要结局
Clinical pregnancy rate
时间窗: 6 weeks after embryo transfer
Number of clinical pregnancies (defined as presence of at least one intrauterine gestational sac with fetal pole and cardiac activity on TVS scan at 4-6 weeks after the ET) divided by the number of ET procedures
次要结局
- Oocyte maturation rate(On 1 day of oocyte retrieval)
研究者
研究点 (1)
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