Saturated Fatty Acids Intake and Mortality, Diabetes, Hypertension and Overweight

Completed

• Conditions: Diabetes; Morality; Hypertension; Overweight

• Registration Number: NCT03281512
• Lead Sponsor: Zhejiang University

Brief Summary

The role of saturated fatty acids (SFAs) intake in the development of total death, cardiovascular diseases, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is scant.The investigators aim to use the data from the China Health and Nutrition Survey to assess the long-term association of SFAs intake with total mortality, diabetes, hypertension and overweight.

Detailed Description

The role of saturated fatty acids (SFAs) intake in the development of total death, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is lacking.The investigators aim to utilize the data from the China Health and Nutrition Survey. The investigators will calculate the cumulative average intake of SFAs based on 3 consecutive 24-h dietary recalls in each round.Sex-specific Cox regression models will be used to estimate the relative risk.Results from our work will be used to provide epidemiological evidence for improving recommendation on SFAs intake for Chinese in dietary guidelines.

Study Timeline

• Study Start: 1989-01-01
• Primary Completion: 2011-12-31
• Study Completion: 2012-12-31
• Study First Submitted: 2017-09-11
• Study First Submitted QC: 2017-09-11
• Study First Posted: 2017-09-13
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-12
• Last Update Posted: 2024-03-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14383

Inclusion Criteria

• Adults aged ≥20 with complete data on diet and follow-up time

Exclusion Criteria

• Cardiovascular diseases
• Diabetes (for analyses of diabetes)
• Body mass index ≥ 24 kg/㎡ (for analyses of overweight)
• Hypertension (for analyses of hypertension)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality	From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to an average of 10 years	Incidence of all-cause death, on basis of household members' report
Diabetes	From entry into the study (baseline: 1997-2009) until 2011	Incidence of diabetes, on basis of self-reported physician diagnosis, fasting plasma glucose ≥ 7.0 mmol/l or HbA1c ≥ 6.5%

Secondary Outcome Measures

Name	Time	Method
Hypertension	From entry into the study (baseline: 1997-2009) until 2011	Incidence of hypertension, on basis of self-reported physician diagnosis, systolic pressure ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg
Saturated fatty acids intake	From entry into the study (baseline: 1997-2009) until 2011	Cumulative average intake of saturated fatty acids on basis of 3 consecutive 24-h dietary recalls
Overweight	From entry into the study (baseline: 1997-2009) until 2011	Incidence of overweight, on basis of body mass index (BMI), BMI ≥ 24 kg/㎡