Vytorin on Carotid Intima-media Thickness and Overall Rigidity
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 主要终点
- The annual progression of the slope of the maximum average GIM and the arterial rigidity.
研究概览
简要总结
Comparison of the effect on the progression of the carotid intima-media interphase thickness (GIM), arterial rigidity according to the measurement of the pulse wave speed and direct measurement of the carotid and aortic rigidities and an inflammation marker (PCR) in patients with established cardiovascular disease (myocardial infarct, atherosclerotic coronary disease), diabetes mellitus type 2 or equivalent risk of coronary disease and a low density lipoprotein level > 100 mg/dL, treated with simvastatin, pravastatin or the combination of simvastatin-ezetimibe during a period of at least one year.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ldl-C Levels >100 Mg/Dl
- •Patients Who Have Signed The Consent
- •Patients Of ages between 30 and 75 Years Old
- •Patients Of Both Genders
- •Patients With Established Cardiovascular Disease, Diabetes With Or Without Established Cardiovascular Disease
- •Patients Without Previous Treatment With Ezetimibe
排除标准
- 未提供
研究组 & 干预措施
A
Group A: Comparator
干预措施: simvastatin (Drug)
B
Group B: Comparator
干预措施: pravastatin (Drug)
C
Group C: Drug
干预措施: ezetimibe (+) simvastatin (Drug)
结局指标
主要结局
The annual progression of the slope of the maximum average GIM and the arterial rigidity.
时间窗: 1 Year
次要结局
未报告次要终点
研究者
Alejandra Meaney Martinez
MD, PhD
Hospital Universitario 12 de Octubre