ProSat - Effect of Probiotics on Satiety

Not Applicable

Completed

• Conditions: Obesity; Appetite Regulation
• Interventions: Dietary Supplement: placebo; Dietary Supplement: probiotic

• Registration Number: NCT00826761
• Lead Sponsor: University of Copenhagen

Brief Summary

The aim of the ProSat study is to examine the effects of a probiotic capsule containing one of two doses (low and high dose) of Lb. Casei on subjective appetite sensation, ad libitum energy intake, and appetite hormone response in a single meal test and to determine whether the acute effects persist after daily supplementation of the probiotic capsule.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-01
• Study First Submitted: 2009-01-21
• Study First Submitted QC: 2009-01-21
• Study First Posted: 2009-01-22
• Primary Completion: 2009-06
• Status Verified: 2012-06
• Last Update Submitted: 2012-06-14
• Last Update Posted: 2012-06-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• Healthy men and women
• Normal to slight overweight (BMI: 22-28 kg/m2)
• 20-45 years of age

Exclusion Criteria

• Smoking
• Daily medicine use (oral contraceptives excluded)
• Use of pre- and probiotic supplements and foods
• Blood donation 3 months prior to the study
• Hb<8mmol/l
• Chronic illnesses such as hyperlipidemia, diabetes inflammatory diseases
• Pregnancy or breastfeeding
• Elite athletes (>10 hours hard exercise/week)
• Vegetarians

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
3	placebo	-
1	probiotic	High dose Lb. casei
2	probiotic	Low dose Lb. Casei

Primary Outcome Measures

Name	Time	Method
Glucose; Insulin; GLP-1; CCK; PYY; grehlin; PP; amylin; LPS; TNF-alfa; hsCRP; fibrinogen	2013

Secondary Outcome Measures

Name	Time	Method
Subjective appetite measurements; Spontaneous food intake	2012

Trial Locations

Locations (1)

Department of Human Nutrition; 🇩🇰 Frederiksberg, Denmark