Development of Real-time Image-guided Radiotherapy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Breast Cancer
- Sponsor
- Fox Chase Cancer Center
- Enrollment
- 159
- Locations
- 1
- Primary Endpoint
- Develop real-time 4D video imaging guidance with combination use of cone-beam computerized tomography (CBCT) useful for daily setup and target motion tracking in advanced image-guided radiotherapy (IGRT).
- Status
- Terminated
- Last Updated
- 6 years ago
Overview
Brief Summary
The goal is to achieve the maximal radiotherapy tumor dose while sparing the health tissue and critical structures. On-board cone-beam CT (CBCT) scans are routinely acquired prior to dose delivery and matched with simulation CT at the planned treatment positions. Thus, setup or motion errors can be detected and corrected. However, CBCT is not available for situations with gantry collisions such as WBI and TSEB. More importantly, CBCT cannot reveal any irregular respiration or body movement during beam-on time. Thus, it is essential to develop a real-time image system that can detect organ/body motion during beam-on time, and correlate simulation-planning images with prior treatment CBCT images.In this proposed clinical trial, we will cooperate with a 3D camera company (Xigen LLC) to develop novel 4D video imaging techniques and validate the feasibility and accuracy of 4D video image guidance in correlation with 4D CT/CBCT useful for advanced IGRT.
Investigators
Eligibility Criteria
Inclusion Criteria
- •All patients benefit from advanced IGRT can participate to the study except for those emergent and pediatric patients (age \<18 years) who require special care or there is no time for the setup the 4D video systems
- •The patient population would be selected according to the technical progress and clinical needs
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Develop real-time 4D video imaging guidance with combination use of cone-beam computerized tomography (CBCT) useful for daily setup and target motion tracking in advanced image-guided radiotherapy (IGRT).
Time Frame: 12 years
Real time 4-D video imaging in combination with CBCT to detect appropriate delivery of radiotherapy
Secondary Outcomes
- To correlate real-time 4D surface images with the internal structures shown in daily XVI volumetric images(12 years)