Effect of Ketogenic Diet on Muscle Hypertrophy

Not Applicable

Recruiting

• Conditions: Healthy Nutrition
• Interventions: Other: resistance training; Other: western diet; Other: ketogenic diet

• Registration Number: NCT05897567
• Lead Sponsor: University of Padova

Brief Summary

The purpose of this study is to investigate the effects of 4 weeks of carbohydrate deprivation (through a ketogenic diet) on hypertrophy signalling after a single bout of exercise in healthy trained male subjects, and the impact on body composition, muscle strength, and blood parameters.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-05
• Study First Submitted: 2023-05-18
• Study First Submitted QC: 2023-06-08
• Study First Posted: 2023-06-09
• Study Start: 2023-06-20
• Last Update Submitted: 2024-05-08
• Last Update Posted: 2024-05-10
• Primary Completion: 2025-03-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Male
• Target Recruitment: 24

Inclusion Criteria

• at least 2 years of resistance-training experience
• Body mass index: more than 18 kg/m2 and less than 30 kg/m2

Exclusion Criteria

• metabolic diseases or noncommunicable diseases (cardiovascular, liver, respiratory, cancer, etc)
• experience with the ketogenic diet (last six months)
• acute inflammatory status
• treatment with steroids in the past 3 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
western diet	resistance training	Participants will perform a single exercise bout after 4 weeks of resistance training combined with a western diet (WD group).
western diet	western diet	Participants will perform a single exercise bout after 4 weeks of resistance training combined with a western diet (WD group).
ketogenic diet	resistance training	Participants will perform a single exercise bout after 4 weeks of resistance training combined with a ketogenic diet (KD group).
ketogenic diet	ketogenic diet	Participants will perform a single exercise bout after 4 weeks of resistance training combined with a ketogenic diet (KD group).

Primary Outcome Measures

Name	Time	Method
mammalian target of rapamycin (mTOR) signalling	Change from baseline to 4 weeks	Measurement of the change in muscle protein anabolic signalling pathway in response to a single bout of resistance exercise by western blot analysis.

Secondary Outcome Measures

Name	Time	Method
Skeletal muscle mass	Change from baseline to 4 weeks	Measurement of the change in kilograms of muscle mass via Dexa

Trial Locations

Locations (1)

Nutex LAB; 🇮🇹 Padua, Italy