Bortezomib (Velcade®) and Reduced-Intensity Allogeneic Stem Cell Transplantation for Patients With Lymphoid Malignancies
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Disease-free Survival
研究概览
简要总结
This phase II trial studies the side effects and best dose of bortezomib when given with chemotherapy and to see how well they work in treating participants with lymphoid malignancies undergoing stem cell transplant. Giving chemotherapy before a stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. When the healthy stem cells from a donor are infused into the participant they may help the participant's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells called graft versus host disease. Giving tacrolimus and methotrexate after the transplant may stop this from happening. Giving bortezomib and chemotherapy may work better in treating participants with lymphoid malignancies undergoing a stem cell transplant.
详细描述
PRIMARY OBJECTIVES:
I. To determine the maximum tolerated dose (MTD) and dose limiting toxicity (DLT) of Velcade (bortezomib) in patients with lymphoid malignancies undergoing allogeneic peripheral blood stem cell or bone marrow transplantation.
II. To determine the 1-year disease-free-survival (DFS) and the toxicity profile of Velcade (bortezomib) in patients with lymphoid malignancies undergoing allogeneic peripheral blood stem cell or bone marrow transplantation.
SECONDARY OBJECTIVES:
I. To compare the incidence of graft versus host disease (GVHD) with historical controls.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- — 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any histological subtype of CD20+ lymphoid malignancies or T-cell lymphoid malignancies.
- •Patients with CD20+ lymphoid malignancies in relapse after failing >= 1 prior regimen of conventional treatment and not eligible for non-myeloablative transplant. Patients with T-cell lymphoid malignancies can either be in relapse or newly diagnosed with high risk features (such as high International Prognostic Index [IPI] of >= 2).
- •Patients with prior non-myeloablative transplant are eligible if not from the same donor.
- •A fully-matched or one-antigen mismatched sibling or unrelated donor.
- •Left ventricular ejection fraction (EF) >= 40% with no uncontrolled arrhythmias or symptomatic heart disease.
- •Forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and diffusion capacity of the lung for carbon monoxide (DLCO) >= 40%.
- •Serum creatinine < 1.8 mg/dL.
- •Serum bilirubin < 3 X upper limit of normal.
- •Serum glutamate pyruvate transaminase (SGPT) < 3 X upper limit of normal.
- •Voluntary signed, written Institutional Review Board (IRB)-approved informed consent before performance of any study-related procedure not part of normal medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to future medical care.
- •Men and women of reproductive potential must agree to follow accepted birth control methods for the duration of the study. Female subject is either post-menopausal or surgically sterilized or willing to use an acceptable method of birth control (i.e., a hormonal contraceptive, intra-uterine device, diaphragm with spermicide, condom with spermicide, or abstinence) for the duration of the study. Male subject agrees to use an acceptable method for contraception for the duration of the study.
排除标准
- •Past history of anaphylaxis following exposure to rituximab or Velcade, boron or mannitol.
- •History of grade 3 or 4 National Cancer Institute (NCI) toxicity with prior Velcade therapy.
- •Patient with active central nervous system (CNS) disease.
- •Pregnant (positive beta human chorionic gonadotropin [HCG] test in a woman with child bearing potential defined as not post-menopausal for 12 months or no previous surgical sterilization) or currently breast feeding. Pregnancy testing is not required for post-menopausal or surgically sterilized women.
- •Known infection with human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV-I), hepatitis B, or hepatitis C.
- •Patients with other malignancies diagnosed within 2 years prior to study day -13 (except skin squamous or basal cell carcinoma).
- •Active uncontrolled bacterial, viral or fungal infections.
- •Major surgical procedure or significant traumatic injury within 4 weeks prior to day -
- •Serious, non-healing wound, ulcer, or bone fracture.
- •History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 3 months prior to day -
- •History of stroke within 6 months.
- •Myocardial infarction within the past 6 months prior to study day 1, or has New York Heart Association (NYHA) class III or IV heart failure or arrhythmia, unstable angina, uncontrolled congestive heart failure or arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities. Prior to study entry, any electrocardiography (ECG) abnormality at screening must be documented by investigator as not medically relevant.
- •Uncontrolled hypertension (>= 140/90).
- •Uncontrolled chronic diarrhea.
- •A prior allogeneic transplant from the same donor.
- •Serious medical or psychiatric illness likely to interfere with participation in this clinical study.
- •Patient has received other investigational drugs within 3 weeks before enrollment.
- •Active peripheral neuropathy greater or equal to grade 2.
研究组 & 干预措施
Treatment (chemotherapy, transplant, filgrastim, tacrolimus)
See Detailed Description
干预措施: Allogeneic Hematopoietic Stem Cell Transplantation (Procedure)
Treatment (chemotherapy, transplant, filgrastim, tacrolimus)
See Detailed Description
干预措施: Anti-Thymocyte Globulin (Biological)
Treatment (chemotherapy, transplant, filgrastim, tacrolimus)
See Detailed Description
干预措施: Bortezomib (Drug)
Treatment (chemotherapy, transplant, filgrastim, tacrolimus)
See Detailed Description
干预措施: Carmustine (Drug)
Treatment (chemotherapy, transplant, filgrastim, tacrolimus)
See Detailed Description
干预措施: Cytarabine (Drug)
Treatment (chemotherapy, transplant, filgrastim, tacrolimus)
See Detailed Description
干预措施: Etoposide (Drug)
Treatment (chemotherapy, transplant, filgrastim, tacrolimus)
See Detailed Description
干预措施: Filgrastim (Biological)
Treatment (chemotherapy, transplant, filgrastim, tacrolimus)
See Detailed Description
干预措施: Melphalan (Drug)
Treatment (chemotherapy, transplant, filgrastim, tacrolimus)
See Detailed Description
干预措施: Methotrexate (Drug)
Treatment (chemotherapy, transplant, filgrastim, tacrolimus)
See Detailed Description
干预措施: Rituximab (Biological)
Treatment (chemotherapy, transplant, filgrastim, tacrolimus)
See Detailed Description
干预措施: Tacrolimus (Drug)
结局指标
主要结局
Disease-free Survival
时间窗: At 1 year
To determine DFS at 1 year post transplant.
Number of Participants With Dose Limiting Toxicity (DLT)
时间窗: From start of treatment to 90 days after the start of treatment
To determine the maximum tolerated dose(MTD) of velcade and dose limiting toxicity(DLT). A dose limiting toxicity (DLT) was defined as a grade 3-4 neurological toxicity, graft failure, or death due to GvHD. The Commom Terminlogy Criteria for Adverse Events v3.0 was used.
次要结局
未报告次要终点