Compensatory Brain Mechanisms for Amygdala-associated Cognitive Dysfunction: Potential Role of the Cortical Mirror Neuron System
- Conditions
- Healthy
- Registration Number
- NCT03723733
- Lead Sponsor
- University of Electronic Science and Technology of China
- Brief Summary
Identify if the mirror neuron system, or other networks, can compensate for amygdala dysfunction, using behavior and structural/functional MRI.
- Detailed Description
In the present study, investigators aim to investigate amygdala dysfunction \& potential compensation in individuals with high and low traits (e.g. Autism, Anxiety, Depression traits, Alexithymia), high and low stress or protective factors in the environment (social network, early life stress) and different molecular genetic make-up. On the neural level, functional and structural connectivity as well as task-related BOLD activation will be assessed.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 350
Inclusion Criteria
- Healthy subjects
Exclusion Criteria
- history of head injury
- claustrophobia;
- medical or psychiatric illness
- female subjects were pregnant or taking oral contraceptives.
- taking any form of medication and drunk any caffeine-containing beverages on the day of the experiment.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method brain activity and connectivity during social and cognitive tasks 2 hours brain activity and connectivity was measured by the fMRI scanner
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
China, Sichuan
🇨🇳Chengdu, Sichuan, China