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Clinical Trials/NL-OMON54480
NL-OMON54480
Not yet recruiting
Not Applicable

Induction of neo*antigen specific cytotoxic T cells by autologous tumor lysate-loaded specialized cross*presenting dendritic cells in epithelial ovarian cancer patients treated with neoadjuvant chemotherapy, the NEODOC study - NEOadjuvant Dendritic cell vaccination for Ovarian Cancer (NEODOC)

Radboud Universitair Medisch Centrum0 sites10 target enrollmentTBD
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Conditionsepithelial ovarian cancerhigh grade serous ovarian cancerovarian cancer10038594

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
epithelial ovarian cancer
Sponsor
Radboud Universitair Medisch Centrum
Enrollment
10
Status
Not yet recruiting
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
last year
Study Type
Interventional

Investigators

Eligibility Criteria

Inclusion Criteria

  • •Age over 18 years old
  • •Histologically confirmed primary epithelial ovarian cancer
  • •Not amenable by primary debulking surgery and in need of neoadjuvant
  • •chemotherapy and interval debulking
  • •High\-grade serous histology
  • •FIGO stage IIIb, IIIc, IVa or IVb if only lymph nodes \<\= 1cm above the
  • •diaphragm or in the groins
  • •Extensive abdominal spread of tumor
  • •WHO/ECOG performance status 0\-1

Exclusion Criteria

  • •Recurrent ovarian cancer
  • •History of any second malignancy, with the exception of adequately treated
  • •basal cell carcinoma, cervical cancer \> 5 years ago or early stage breast
  • •cancer \>10 years ago.
  • •Any serious clinical condition that may interfere with the safe
  • •administration of DC vaccinations or renders patient ineligible for combined
  • •carboplatin\-paclitaxel chemotherapies
  • •Active infection of Hepatitis B, C, HIV and syphilis or any other serious
  • •active infection
  • •Known allergy to shell fish

Outcomes

Primary Outcomes

Not specified

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