Micrometastases in Axillary Lymph Nodes in Breast Cancer, Post-neoadjuvant Chemotherapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 978
- 主要终点
- Recurrence-free survival
研究概览
简要总结
This study aims to investigate the significance of minimal residual axillary disease following NAC, with a particular focus on micrometastases (ypNmi), in comparison to pathologic lymph node-negative (ypN0) or macrometastases (ypN+). The investigators will further explore the prognostic implications of SLNmi for the prediction of axillary LN status and survival outcomes.
详细描述
This study aims to investigate the significance of minimal residual axillary disease following NAC, with a particular focus on micrometastases (ypNmi), in comparison to pathologic lymph node-negative (ypN0) or macrometastases (ypN+). The investigators will further explore the prognostic implications of SLNmi for the prediction of axillary LN status and survival outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Stage II or III primary breast cancer patients
- •Patients who performed neoadjuvant chemotherpay
- •Patients who underwent axillary lymph node dissection with or without sentinel lymph node biopsy
排除标准
- •Patients who performed upfront surgery
- •De novo stage IV patients
结局指标
主要结局
Recurrence-free survival
时间窗: the interval from breast cancer diagnosis to the initial recurrence or death upto 5 years
locoregional recurrence, distant metastasis, any cause of death
次要结局
未报告次要终点
研究者
Joon Jeong
Proffesor
Gangnam Severance Hospital