Study of Brain Activity in Candidates for Epilepsy Surgery
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Electrophysiological recordings: LFP
Study Overview
Brief Summary
Prospective interventional study with implantation of micro-electrodes to study the brain networks in epilepsy at high spatiotemporal resolution.
Detailed Description
The goal of this trial is to study brain activity in epilepsy at high spatiotemporal resolution. Apart from the epileptogenic network (dysfunctional areas), the investigators will study human brain function.
The use of micro-electrode arrays allows to study the human brain a high spatiotemporal resolution, even at the single neuron level.
Scientific objectives of the current project:
- To record neural signals from macro-electrodes and delineate the epileptogenic network and study brain function during specific tasks.
- To record neural signals from micro-electrodes and delineate the epileptogenic network and study brain function during specific tasks.
- Identifying pivotal regions for BMI applications and developing online decoding algorithms.
- Comparing neural recordings to fMRI activity
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 90 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age ≥18 yo
- •Epilepsy patients undergoing intracranial electrode placement.
- •Able to understand the procedure involved and to consent.
Exclusion Criteria
- •Age < 18 yo
- •Pregnancy
Arms & Interventions
micro/macro electrode
Intervention: macro/micro electrode recording (Device)
Outcomes
Primary Outcomes
Electrophysiological recordings: LFP
Time Frame: 15 years
The investigators will investigate the epileptogenic network by recording neural activity at different spatiotemporal scales and using different modalities. The investigators will be looking at \* Electrophysiological recordings: \- local field potentials (LFP) (outcome measure: mainly power in the beta and gamma band, but also alfa and theta band)
Electrophysiological recordings: single neuron recordings
Time Frame: 15 years
The investigators will investigate the epileptogenic network by recording neural activity at different spatiotemporal scales and using different modalities. The investigators will be looking at \* Electrophysiological recordings: \- single neuron recordings (outcome measure: spike rate)
fMRI recordings
Time Frame: 15 years
\* fMRI recordings (outcome measure: Blood Oxygen Level Dependent (BOLD) signal increases/decreases) By performing electrophysiological recordings and fMRI recordings in the same subjects, we will be able to compare both modalities with each other.
Secondary Outcomes
- Neurophysiological study of different brain areas: power gamma band(15 years)
- Neurophysiological study of different brain areas: spike activity(15 years)
- Neurophysiological study of different brain areas: fMRI(15 years)
Investigators
Tom Theys
Principal Investigator
Universitaire Ziekenhuizen KU Leuven