Study of Brain Activity in Candidates for Epilepsy Surgery
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- fMRI recordings
研究概览
简要总结
Prospective interventional study with implantation of micro-electrodes to study the brain networks in epilepsy at high spatiotemporal resolution.
详细描述
The goal of this trial is to study brain activity in epilepsy at high spatiotemporal resolution. Apart from the epileptogenic network (dysfunctional areas), the investigators will study human brain function.
The use of micro-electrode arrays allows to study the human brain a high spatiotemporal resolution, even at the single neuron level.
Scientific objectives of the current project:
- To record neural signals from macro-electrodes and delineate the epileptogenic network and study brain function during specific tasks.
- To record neural signals from micro-electrodes and delineate the epileptogenic network and study brain function during specific tasks.
- Identifying pivotal regions for BMI applications and developing online decoding algorithms.
- Comparing neural recordings to fMRI activity
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 yo
- •Epilepsy patients undergoing intracranial electrode placement.
- •Able to understand the procedure involved and to consent.
排除标准
- •Age < 18 yo
- •Pregnancy
结局指标
主要结局
fMRI recordings
时间窗: 15 years
\* fMRI recordings (outcome measure: Blood Oxygen Level Dependent (BOLD) signal increases/decreases) By performing electrophysiological recordings and fMRI recordings in the same subjects, we will be able to compare both modalities with each other.
Electrophysiological recordings: LFP
时间窗: 15 years
The investigators will investigate the epileptogenic network by recording neural activity at different spatiotemporal scales and using different modalities. The investigators will be looking at \* Electrophysiological recordings: \- local field potentials (LFP) (outcome measure: mainly power in the beta and gamma band, but also alfa and theta band)
Electrophysiological recordings: single neuron recordings
时间窗: 15 years
The investigators will investigate the epileptogenic network by recording neural activity at different spatiotemporal scales and using different modalities. The investigators will be looking at \* Electrophysiological recordings: \- single neuron recordings (outcome measure: spike rate)
次要结局
- Neurophysiological study of different brain areas: power gamma band(15 years)
- Neurophysiological study of different brain areas: spike activity(15 years)
- Neurophysiological study of different brain areas: fMRI(15 years)
研究者
Tom Theys
Principal Investigator
Universitaire Ziekenhuizen KU Leuven