Chronic Kidney Disease at Northeast Taiwan: Biomarker and Multidisciplinary Care

Not Applicable

Recruiting

• Conditions: Chronic Kidney Disease

• Registration Number: NCT04300387
• Lead Sponsor: Chang Gung Memorial Hospital

Brief Summary

CKD is a global endemic disease with increased comorbidities and mortality. The prevalence and the incidence of the end-stage renal disease (ESRD) are extremely high in Taiwan. Early diagnosis of disease and proper management remain challenging. The aims of this study are:

1. Explore risk factors associated with CKD

2. Establish multidisciplinary care model for CKD patients

3. Development cost-effective clinical care pathway for CKD

4. Provide bio-specimen repository for future study

Detailed Description

CKD is a global endemic disease with increased comorbidities and mortality. The prevalence and the incidence of the end-stage renal disease (ESRD) are extremely high in Taiwan. Early diagnosis of disease and proper management remain challenging. The aims of this study are:

1. Explore risk factors associated with CKD: demographic, social and genetics factors

2. Establish multidisciplinary care model for CKD patients

3. Development cost-effective clinical care pathway for CKD

4. Provide bio-specimen repository for future study: serum, PBMC, urine and stool

Study Timeline

• Study Start: 2011-03
• Study First Submitted: 2016-09-30
• Status Verified: 2020-03
• Study First Submitted QC: 2020-03-06
• Last Update Submitted: 2020-03-06
• Study First Posted: 2020-03-09
• Last Update Posted: 2020-03-09
• Primary Completion: 2024-12
• Study Completion: 2024-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 8000

Inclusion Criteria

• Subjects visiting outpatient clinics of nephrology of Chang Gung Memorial Hospital

Exclusion Criteria

• Patient receiving dialysis or transplantation
• Unwilling to participate

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
difference of US dollars	through study completion, every 1 year	differences of US dollars of medical care (out patients and inpatients service fees) between groups
percentage (%)	through study completion, every 1 year	percentage of patients with new CKD, starting dialysis treatments, cardiovascular event or mortality

Secondary Outcome Measures

Name	Time	Method
fold changes of microRNA	through study completion, every 1 year	change of levels between groups
fold changes of proteins	through study completion, every 1 year	change of levels between groups

Trial Locations

Locations (1)

Chang Gung Memorial Hospital; 🇨🇳 Keelung, Taiwan