FORTUNA(Evaluation of Fractional Flow Reserve Calculated by Computed Tomography Coronary Angiography in Patients undergoing Transcatheter Aortic Valve Replacement)
- Conditions
- severe aortic stenosis
- Registration Number
- JPRN-UMIN000033357
- Lead Sponsor
- Division of Cardiovascular Medicine, Department of Internal Medicine, Graduate School of Medicine, Kobe University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 25
Not provided
Patients who meet any one of the following criteria will be excluded from this study: 1)Patients who were implanted with metal stents in the left main trunk, 2)Patients with stenosis of >30% in the left main trunk who were implanted with at least one metal stent in the vessel(s) of the left coronary circulation, 3)Patients who were implanted with metal stents in at least 2 vessels of the coronary circulation, 4)Patients who requested withdrawal of consent for participation in this research study after providing their consent, 5)Patients who underwent coronary artery bypass surgery, 6)Patients with coronary artery chronic total occlusion, 7)Patients who developed acute myocardial infarction in the past 2 months, 8)Patients whose CCTA was determined to be unreadable during its evaluation at the study site because of the presence of artifacts which were severe enough to cause problems with the angiogram, 9)Patients who were judged by the principal investigator to be unsuitable for the study for other reasons
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method A cut-off value for FFRct that can estimate FFR of <0.80 in patients with severe AS
- Secondary Outcome Measures
Name Time Method (1)A cut-off value for pre-TAVR iFR that can estimate FFR of <0.80 in patients with severe AS (2)Regression and correlation coefficient of FFRct before TAVR and after TAVR (3)Regression and correlation coefficient of iFR before TAVR and after TAVR (4)Stenosis degree in coronary angiography before TAVR predicting FFR: <0.80 in severe AS patients