The Efficacy of Oral Antiseptics Against COVID-19

Phase 4

Completed

• Conditions: COVID-19
• Interventions: Drug: Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO)

• Registration Number: NCT05214196
• Lead Sponsor: Ataturk University

Brief Summary

In a study conducted on 75 COVID-19 patients, the effect of SARS-CoV-2 on viral load was investigated as a result of the use of hypochlorous acid and povidone-iodine as an oral antiseptic.

Detailed Description

Before and 30 minutes after rinsing with mouth antiseptics, the participants were asked to rinse the mouth and throat for 30 seconds with 0.9% isotonic saline. The sample was sputtered into a sterile plastic container. The participants were grouped according to the type of oral antiseptics used. The effectiveness of SARS-CoV-2 viral load was investigated by rinsing the mouth and throat for 30 seconds with 20 ml of hypochlorous acid, povidone-iodine, and isotonic saline. Viral load was analyzed by RT-PCR analysis. The results were evaluated by statistical analysis.

Study Timeline

• Study Start: 2021-09-01
• Primary Completion: 2021-12-01
• Study Completion: 2021-12-07
• Status Verified: 2022-01
• Study First Submitted: 2022-01-25
• Study First Submitted QC: 2022-01-25
• Study First Posted: 2022-01-28
• Last Update Submitted: 2022-01-28
• Last Update Posted: 2022-02-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• Positive SARS-CoV-2 RT-PCR result,
• Adult hospitalized patient,
• The participants have the physical and psychological ability to follow the instructions in the study.

Exclusion Criteria

• Patients intubated and supported by a mechanical respirator,
• Severe acute or chronic medical or psychiatric condition,
• History of significant adverse effects following use of oral hygiene products such as toothpaste and mouth rinses,
• Active uncontrolled thyroid disease,
• Developmental/cognitive disability,
• Pregnancy,
• Undergoing radioactive iodine therapy.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Hypochlorous acid group	Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO)	The effect of 0.02% Hypochlorous acid solution on viral load was investigated by using 25 COVID-19 patients as an oral antiseptic for 30 seconds.
Povidone-iodine group	Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO)	The effect on viral load was investigated by using 0.5% Povidone-iodine solution as an oral antiseptic for 30 seconds in 25 COVID-19 patients.
Saline group	Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO)	The effect on viral load was investigated by using 0.9% isotonic saline solution as a placebo for 30 seconds in 25 COVID-19 patients.

Primary Outcome Measures

Name	Time	Method
RT-PCR analysis	two weeks	For the quantitative analysis of the amount of SARS-CoV-2 RNA in the obtained samples, the Real-time Reverse Transcyptase Polymerase Chain Reaction method was used.

Trial Locations

Locations (1)

Atatürk University Faculty of Dentistry; 🇹🇷 Erzurum, Turkey