A Randomized Controlled Clinical Study to Evaluate the Efficacy of Sharbat -e- Bazoori Moatadil Versus Nitrofurantoin in Pediatric Urinary Tract Infection.
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
研究概览
简要总结
Urinary tract infections UTIs are one of the most common bacterial infections in childhood affecting approximately 7.8percent of children
There are different clinical symptoms of UTI such as cystitis pyelonephritis asymptomatic bacteriuria chronic and recurrent UTIs of which cystitis is the most frequent presentation affecting the urinary bladder If prompt treatment is not received the bacteria may continue to grow in the urinary tract and cause a kidney infection Between 75 and 95 percent of all cases of uncomplicated UTI are community acquired and are brought on by uropathogenic E. coli UPEC and Klebsiella spp. The most prevalent uropathogen was found to be E. coli followed by K. pneumoniae
Symptoms are classified by severity Minor pyrexia adequate fluid intake minor dehydration and good treatment compliance are characteristics of mild UTIs Lower UTIs represent the majority of mild UTIs
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 3.00 Year(s) 至 18.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients of both genders aged 3 to 18 years diagnosed with uncomplicated UTI.
- •Signs and symptoms consistent with UTI (e.g., fever, dysuria, frequency, suprapubic pain,) plus a positive urine analysis (pyuria equal or more than 5 WBC per HPF or positive leukocyte esterase per nitrite) or positive urine culture (more than 105 CFU per mL for midstream clean-catch or per local diagnostic cut-offs).
- •First episode or non-complicated recurrent UTI (equal or less than 2 episodes in past 12 months).
- •Patient’s guardian or parents willing to sign the informed consent form and follow the study protocol.
排除标准
- •Complicated UTI ( e.g., pyelonephritis with systemic toxicity, urosepsis, prostatitis etc.) Structural or functional urinary tract abnormality.
- •Recent antibiotic used ( Use of systemic antibiotics active against urinary pathogens within 48–72 hours prior to screening).
- •Exclude culture sensitive proven Nitrofurantoin resistant cases.
- •Patient is unsure about attending schedule regularly.
研究者
Mo Azahar
State Unani Medical College and Hospital