Long Term Follow up in Sickle Cell Patients Treated by Hydroxyurea

Completed

• Conditions: Sickle Cell Anemia; Sickle Cell Thalassemia
• Interventions: Other: Clinical follow up and laboratory analysis

• Registration Number: NCT00480974
• Lead Sponsor: HaEmek Medical Center, Israel

Brief Summary

Hydroxyurea was found to be a good treatment in adult patients with sickle cell anemia with significant decrease in the frequency of vaso-occlusive crises and other crises related to SCA. Several studies were published with relative short term follow up in pediatric and young adult age. The purpose of this study is to assess the long term follow up in a group of patients that initiated Hydroxyurea treatment in childhood.

Detailed Description

Hydroxyurea was found to be a good treatment in adult patients with sickle cell anemia with significant decrease in the frequency of vaso-occlusive crises and other crises related to SCA. Several studies were published with relative short term follow up in pediatric and young adult age. The purpose of this study is to assess the long term follow up in a group of patients that initiated Hydroxyurea treatment in childhood.

A long term follow up will be recorded in a cohort of twenty SCA patients treated by Hydroxyurea for a period between 5 to 12 years. The frequency of vaso-occlusive crises, acute chest syndrome, blood transfusions, and hospitalization will be recorded retrospectively. Also the mean hgb level and hgb F percentage will be summarized.

Study Timeline

• Study Start: 2007-05
• Study First Submitted: 2007-05-31
• Study First Submitted QC: 2007-05-31
• Study First Posted: 2007-06-01
• Primary Completion: 2008-12
• Study Completion: 2008-12
• Status Verified: 2009-09
• Last Update Submitted: 2009-09-03
• Last Update Posted: 2009-09-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• All patients treated by Hydroxyurea in the Pediatric Hematology Unit.

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1	Clinical follow up and laboratory analysis	Patients with Sickle cell anemia treated by Hydroxyurea

Trial Locations

Locations (1)

Pediatric Hematology Unit - HaEmek Medical Center; 🇮🇱 Afula, Israel