Evaluation of the Epidemiological and Psychosocial Outcomes of Liver Graft Recipients Transplanted During Childhood
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- assessing the epidemiological and social impact of pediatric liver transplantation
研究概览
简要总结
The main objective of this study is to better characterize the adult population with a history of liver transplantation in pediatric age. In this context, the investigators will use a questionnaire to assess the participants social environment and lifestyle habits and validated scales to assess their alcohol consumption and anxiety levels.
Secondly, the investigators would like to assess the participants knowledge of their disease, their experience of the transition period from pediatrics to adult medicine, and their compliance with medication.
详细描述
Outcomes after pediatric liver transplantation have improved in recent years, thanks to improvements in surgical techniques, immunosuppressive drugs and postoperative management in pediatric hepatology departments. For some diseases, transplantation has become the only way to save the lives of these children, or to ensure them a better quality of life.
Indications for pediatric liver transplantation can be categorized as follows: Cholestatic condition, hepatitis, metabolic diseases, tumors and orther conditions such as Gestational alloimmune liver disease, drug induced liver diseases, ect.
Short- and long-term complications following liver transplantation have been the subject of numerous studies.
These include mainly biliary and vascular complications, rejection and infections (including EBV viral infections, which can lead to post-transplant lymphoproliferative disorder).
A recent study showed that in the long term, only 32% of children with liver transplants had an "ideal outcome" defined as a first allograft stable on immunosuppression monotherapy, normal growth, and absence of common immunosuppression-induced sequelae.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any patient over 18 years old who received a pediatric liver transplant and who have been followed regularly at the Saint-Luc university clinics is eligible for inclusion in this study provided they speak French/Dutch fluently
排除标准
- •patients minor (< 18 years)
结局指标
主要结局
assessing the epidemiological and social impact of pediatric liver transplantation
时间窗: 1 year
To better characterize the adult population with a history of liver transplantation in pediatric age. In this context, we will use a questionnaire to assess : * social environment (level of education, social status, employment, sexual orientation...) * lifestyle habits (risk-taking behavior, diet, exercise, weight, height...) * validated scales to assess their alcohol consumption and anxiety levels (AUDIT, BDI, STAI)
次要结局
- assessing their knowledge of their disease, their experience of the transition period from pediatrics to adult medicine, and their compliance with medication(1 year)