Colon Capsule Endoscopy in Bowel Cancer Screening. A Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Colorectal Cancer
- Sponsor
- Odense University Hospital
- Enrollment
- 2031
- Locations
- 1
- Primary Endpoint
- CCE detection rate of polyps compared to OC
- Status
- Completed
- Last Updated
- 7 months ago
Overview
Brief Summary
The investigatior believe that implementing camera capsule endoscopy as a filter test to colonoscopy will increase screening participation, increase the number of individuals with detected intermediate- high risk adenomas or cancer, reduce the colonoscopy demand and reduce the number of complications.
Detailed Description
The Danish national colorectal cancer screening program includes all citizens aged 50-74 years, who are invited biennially to a fecal test for invisible blood in the stool. If the test is positive the citizen is invited for a colonoscopy. 90% of the test-positive undergo colonoscopy. The detected cancers are at a significant earlier stage and survival from screening detected cancer is higher. It is also expected that cancer incidence will drop due to removal of the advanced adenomas before they develop into cancer. Although initial results are positive, there is room for improvement. Additionally there are rare but serious complications to colonoscopy in the form of bleeding or bowel perforation. Through four years the investigators have tested the colon capsule endoscopy method, and find that the investigation is associated with significantly less discomfort and that the diagnostic ability to find polyps \> 1 cm is better than colonoscopy.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Participation in the Danish colorectal screening program
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
CCE detection rate of polyps compared to OC
Time Frame: Within 30 days
The investigators aim to conduct a large scale randomized trial to investigate the implementation of CCE as part of the Danish screening protocol.