Vitamin C status in patients with chronical kidney disease

Completed

Conditions: vitamin C deficiency
chronic kidney disease
10047635
10038430

Registration Number: NL-OMON40228

Lead Sponsor: Dialyse Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 140

Inclusion Criteria

Predialysis patients with minimal 3 months ECC <= 20 ml/min
Kidney transplantation patients: minimal 6 months after kidney transplantion with ECC >= 30 ml/min
PD patients: minimal 3 months peritoneal dialysis treatment
CHD patients: 3 x per week 4 hours dialysis (± 12 hours dialysis per week), minimal 3 months hemodialysis treatment
NCHD patients: every other night 8 hours dialysis (± 28 hours dialysis per week), minimal 3 months in nocturnal hemodialysis treatment

Exclusion Criteria

Malabsorption, gastro intestinal diseasese, oncological diseases, and absence of informed consent.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Predialysis patients: plasma vitamin C level; 2. NTx patients: plasma<br /><br>vitamin C level; 3. PD patients: plasma vitamin C level, 4. CHD patients:<br /><br>plasma vitamin C levels before, during and after dialysis; 5. NCHD patients:<br /><br>plasma vitamin C levels before, during and after dialysis. In all groups<br /><br>vitamin C intake will be assessed using a 24-hour recall questionnaire. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>CHD (3 dialysate measurements),<br /><br>- vitamin C measurements from the dialysate: 15 minutes after start dialysis,<br /><br>after 2 hours dialysis, and 15 minutes before the end of the dialysis treatment.<br /><br>- total Kt/V (dialysis efficiency).<br /><br>NCHD (4 dialysate measurements),<br /><br>- vitamin C measurements from the dialysate: 15 minutes after start dialysis,<br /><br>after 3 hours dialysis, after 6 hours dialysis, and 15 minutes before the end<br /><br>of the dialysis treatment.<br /><br>- total Kt/V (dialysis effciency).<br /><br><br /><br>Laboratory measurements: Hemoglobin, sodium, potassium, urea, creatinine,<br /><br>alkaline phosphatase, calcium, phosphate, albumin, ferritin, TSAT, CRP, PTH<br /><br>(standard monthly measurements)</p><br>