Mindreading in Adults With Autism Spectrum Disorder

Recruiting

• Conditions: Autism Spectrum Disorder
• Interventions: Other: no intervention

• Registration Number: NCT04010409
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

This study aims to investigate the ability of reading emotions by the Eyes task in adults with ASD, and examine the gazing pattern and frontal activation during the task. We plan to recruit 50 adults with ASD and 50 typically-developing adults. Eye-tracking and frontal activation (measured by functional near-infrared spectroscopy) will be examined during the Eyes task.

Detailed Description

Autism spectrum disorder (ASD) is a clinical syndrome characterized by mindreading deficits, or Theory of Mind deficits. The Reading the Mind in the Eyes task (abbreviated as the Eyes task) was developed to assess the mindreading deficits as a hallmark of social deficits of ASD. This study aims to investigate the ability of reading emotions by the Eyes task in adults with ASD, and examine the gazing pattern and frontal activation during the task. We plan to recruit 50 adults with ASD and 50 typically-developing adults. All the participants will complete clinical measures and the Eyes task. Eye-tracking and frontal activation (measured by functional near-infrared spectroscopy) will be examined during the Eyes task.

Study Timeline

• Study Start: 2019-01-08
• Study First Submitted: 2019-07-04
• Study First Submitted QC: 2019-07-04
• Study First Posted: 2019-07-08
• Status Verified: 2022-12
• Last Update Submitted: 2023-04-13
• Last Update Posted: 2023-04-18
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Adult aged between 20 and 50 years who had a diagnosis of ASD based on DSM-5.
• Had a full-scale IQ > 70 on WAIS-IV.

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Exclusion Criteria

• A history of major mental illness (e.g., bipolar affective disorder, schizophrenia) or neurological diseases.
• Visual impairment and that would preclude participation.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
TD Group	no intervention	Typically developmental controls,no intervention
ASD Group	no intervention	Autism spectrum disorder participants, no intervention

Primary Outcome Measures

Name	Time	Method
eye tracking indicators	30 min	eye tracking indicators

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan