Effects of intraarticular IL1-Ra on pain and inflammatory mediators after knee arthroscopy –a double blind, placebo controlled study using microdialysis technique

ovisenberg Diaconal Hospital0 个研究点开始时间: 2013年7月29日最近更新: 2013年11月4日

试验速览

暂无简介。

•Otherwise healthy patients between 18 and 70 years undergoing diagnostic or therapeutic knee arthroscopy.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 60
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 15

•1.Pregnancy or lactation
•2.Established osteoarthritis or synovitis
•3.Known intolerance to anakinra
•4.Kidney failure (Creatinine clearance <30ml/min)
•5.History of frequent infectious diseases or immunodeficiency
•6.Heart failure
•7.History of drug –or alcohol abuse
•8.Participation in other synchronous clinical trials
•9.Perioperative steroidtreatment, perioperative acetaminophen (12 hrs), NSAIDs (24 hrs) or COX2-inhibitors (48 hrs).
•10.Use of tourniquet for bloodless field
•11.Strong preoperative pain
•12.Intolerable postoperative pain (VRS=4)

发起方

ovisenberg Diaconal Hospital