Clinical outcomes and cardiovascular responses to High Intensity Interval Training versus Moderate Intensity Continuous Training in Heart Failure Patients: A randomized, controlled trial.

Not Applicable

• Conditions: Systolic Heart Failure; Cardiovascular - Other cardiovascular diseases; Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation

• Registration Number: ACTRN12612000511831
• Lead Sponsor: niversity of New England

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-05-14
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

Diagnosis of heart failure by echocardiography LVEF<40% any aetiology is accepted

Exclusion Criteria

Myocardial infarction within prior 12 months.
Change of medical therapy in the 3 months prior to study entry.
Unstable angina
Resting systolic blood pressure > 200 mm Hg, or diastolic blood pressure > 110 mm Hg,
Systemic illness
Fever and critical aortic stenosis (peak systolic pressure gradient > 50 mm Hg with an aortic valve orifice area > 0.75 cm2 in average size adult).
Uncontrolled atrial or ventricular arrhythmias such as uncontrolled sinus tachycardia (> 120 beats.min-1), 3rd degree AV block, active pericarditis or myocarditis, recent embolism, thrombophlebitis and resting ST segment displacement (> 2 mm).
Uncontrolled diabetes (resting blood glucose of > 400 mg/dL)
Severe orthopedic conditions that would prohibit exercise
Other metabolic conditions such as acute thyroiditis, hypokalemia or hyperkalemia and hypovolemia.
dementia; any systemic disease limiting exercise; inability to participate in a prospective study for any logistic reason, chronic inflammatory disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality[ 6 and 12 months]

Secondary Outcome Measures

Name	Time	Method
Peak VO2 (Cardiorespiratory fitness) will be assessed by expired gas analysis during staionary cycling using a 10W per min increment until volitional exhaustion or medical reason to terminate the test is reached.[ 0,1, 2, 3, 4, 5, 6, 12 months];Heart Function by echocardiography (pre and immediately post exercise testing)[ 0,3,6,12 months];Brain Natriuertic Peptide and ST-2 (both assesed by venipuncture, plasma separation and commercial assay)[ 0,3,6,12 months];Quality of life (Minnesota Living with Heart Failure Questionnaire)[ 0,1, 2, 3, 4, 5, 6, 12 months]