Development and Validation of a Screening Tool to Identify the Dominant Pain Mechanism in Cancer Survivors With Persistent Pain
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Conditioned pain modulation
研究概览
简要总结
Development and internal validation of an easy-to-use tool for clinical pain assessment. The tool has to be applicable in any clinical practice and without the need for expensive and complicated hospital tools to identify the source of persistent pain after the treatment of cancer.
详细描述
An adequate selection of physiotherapy treatment for persistent pain after the treatment of cancer, depends highly on the mechanism of the pain.
Pain can arise from a damaged nerve or tissue (skin, lymphatic system...). But when pain becomes chronic, alterations to the central nervous system can occur, as regulations of the facilitating and inhibiting mechanisms. These alterations may cause central sensitization pain. The body is now sensitized and cannot distinct harmful from harmless stimuli.
Each type of pain requires a specific treatment, therefore identification of the pain mechanism is crucial. Up till now, expensive and complex tests were performed in a hospital setting to determine if a patient suffers from neuropathic, nociceptive or central sensitization pain. This study aims for developping an assessment tool that does not require expensive devices but can be easily performed by any physiotherapist, within the timeframe of a standard consultation.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient treated for primary cancer: breast, prostate, lung/bronchus, colon/rectum, gynecologic (uterus or ovary)
- •Complete remission
- •Curative treatment finished
- •Ongoing hormonal and targeted treatment permitted
- •Patient experiences pain (NRS minimum 3/10 during the past week)
排除标准
- •Active metastasis
- •Palliative status
- •Other type of cancer than mentioned in inclusion criteria
- •Pregnancy
结局指标
主要结局
Conditioned pain modulation
时间窗: 10 minutes
Central sensitization pain: pain caused by changes in the central nervous system is assessed with a thermal test (2)
Temporal summation
时间窗: 2,5 minutes
Central sensitization pain: pain caused by changes in the central nervous system is assessed with a series of touch stimuli (3)
Diffuse pain
时间窗: 0,5 minute
Central sensitization pain: pain caused by changes in the central nervous system is assessed by painting affected areas on a body chart (4)
Joint pain
时间窗: 30 seconds
Nociceptive pain: pain that arises from a damaged tissue is assessed by examining if several joints are sore, especially in the morning (3)
Quantitative sensory testing
时间窗: 20 minutes
Neuropathic pain: pain that arises from a damaged nerve is assessed by measuring thermal thresholds (2)
Manual palpation
时间窗: 3 minutes
Central sensitization pain: pain caused by changes in the central nervous system is assessed by applying pressure with manual palpation (5)
Douleur Neuropathic 4 questions (DN4) questionnaire
时间窗: 2 minutes
Neuropathic pain: pain that arises from a damaged nerve is assessed with a questionnaire (1)
Lymphedema
时间窗: 4 minutes
Nociceptive pain: pain that arises from a damaged tissue is assessed by examining the presence of lymphedema by measuring the circumference of the arm (2)
Active mobility
时间窗: 2,5 minutes
Nociceptive pain: pain that arises from a damaged tissue is assessed by examining the movements the patient can perform (4)
Passive mobility
时间窗: 3,5 minutes
Nociceptive pain: pain that arises from a damaged tissue is assessed by examining the movements the clinician can perform on the patient (5)
Strength
时间窗: 1,5 minutes
Nociceptive pain: pain that arises from a damaged tissue is assessed by the strength the patient can perform in a specific movement (6)
Central Sensitization Inventory (CSI) questionnaire
时间窗: 5 minutes
Central sensitization pain: pain caused by changes in the central nervous system is assessed with a questionnaire (1)
Scar tissue
时间窗: 2 minutes
Nociceptive pain: pain that arises from a damaged tissue is assessed by examining the elasticity of the scar tissue by manual palpation of the clinician (7)
Pain mapping
时间窗: 1 minute
Neuropathic pain: pain that arises from a damaged nerve is assessed by painting affected areas on a body chart (3)
Evaluation of skin
时间窗: 20 seconds
Nociceptive pain: pain that arises from a damaged tissue is assessed by visual evaluation of the skin condition (1)
Axillary web syndrome
时间窗: 2 minutes
Nociceptive pain: pain that arises from a damaged tissue is assessed by visually examining the presence of lymph cords in the axilla (8)
次要结局
- Pain disability: Pain Disability Index(3 minutes)
- Pain intensity: Visual Analogue Scale(1 minute)
- Pain Self-efficacy and Expectations: questionnaire(5 minutes)
- Pain catastrophizing scale(6 minutes)
- Depression, anxiety and stress(7 minutes)
- Pain character: questionnaire(4 minutes)
- Pain questionnaire(30 seconds)
研究者
An De Groef
Principal investigator An De Groef
Universitaire Ziekenhuizen KU Leuven