Chinese People's Liberation Army General Hospital
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 10,000
- 主要终点
- Contrast induced nephropathy postoperation
研究概览
简要总结
This review article have included about ten thousand patients undergoing percutaneous coronary intervention (PCI), aim to identify the incidence of CIN in actual, find some new risk factors and the protecting methods for these factors.
详细描述
About ten thousand patients undergoing percutaneous coronary intervention (PCI) from 2010 to 2015 are included in this study. We collect the data about the SCr of the patients before and after percutaneous coronary intervention, and define CIN as an increase in SCr of 0.5 mg/dl or 25% from baseline between 48 and 72 h after contrast medium exposure. Besides we obtain the data including clinical characteristics, laboratory data (blood and urine tests) for all the patients. The statistical analysis will find some new risk factors.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •congestive heart failure: objective evidences for decreased left ventricular eject fraction (LVEF) <= 50%;
- •moderate to severe chronic kidney disease was defined as an eGFR 15 to 59 mL/min per 1.73 m2, calculated via the abbreviated Modification of Diet in Renal Disease (MDRD) study equation from SCr obtained within 72 hours of enrollment;
- •patients were scheduled to undergo diagnostic cardiac angiography or percutaneous coronary interventions.
排除标准
- •hemodialysis-dependent patients;
- •complicated with severe short-term progressive disease;
- •Patients < 18 years;
- •emergency cardiac catheterisation (eg, primary percutaneous coronary intervention for ST-segment elevation myocardial infarction);
- •exposure to radiographic contrast media within the previous 7 days;
- •acute decompensated heart failure.
结局指标
主要结局
Contrast induced nephropathy postoperation
时间窗: 7 days
peak serum creatinine increase of either 0.5 mg/dl or 25% from day 0 through day 7
次要结局
- Composite measure of dialysis or main cardiovascular events(90 days)
研究者
Qian geng
associate chief physician
Chinese PLA General Hospital