A proof-of-concept and dose-finding study of XXB750 in patients with heart failure
Phase 2
Recruiting
- Conditions
- Heart failure
- Registration Number
- JPRN-jRCT2031230649
- Lead Sponsor
- Iwasaki Ryohei
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 18
Inclusion Criteria
Current symptom(s) of HF NYHA class II-III and LVEF < 50%
- Elevated NT-proBNP levels at screening.
- Receiving standard of care background HF therapy.
Exclusion Criteria
- Current acute decompensated HF or hospitalization for HF within 3 months prior to screening.
- Current symptomatic hypotension (for example dizziness/presyncope).
- K+ > 5.4 mmol/L at screening
- eGFR < 30 mL/min/1.73m2 at screening
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in log NT-proBNP from baseline
- Secondary Outcome Measures
Name Time Method