Effects of Gene Polymorphism After Transcranial Cranial Direct Current Stimulation on the Corticobulbar Excitability

Completed

• Conditions: Healthy
• Interventions: Device: tdcs

• Registration Number: NCT03712150
• Lead Sponsor: The Catholic University of Korea

Brief Summary

This study aims to examine the effects of transcranial direct current stimulation at corticobulbar excitability in individuals with different gene polymorphism.

Detailed Description

The effects of TDCS on corticobulbar excitability of the brain after inhibitory pre-conditioning will be compared in patients with different BDNF phenotypes

Study Timeline

• Study First Submitted: 2018-10-10
• Study First Submitted QC: 2018-10-17
• Study First Posted: 2018-10-19
• Study Start: 2018-11-10
• Primary Completion: 2019-06-08
• Study Completion: 2019-08-08
• Status Verified: 2019-11
• Last Update Submitted: 2019-11-05
• Last Update Posted: 2019-11-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Age 19-40 years
• Informed consent

Exclusion Criteria

• History of epilepsy
• Presence of cardiac pacemaker
• previous brain surgery
• previous swallowing problems
• current use of medication which acts on the central nervous system
• presence of implanted metal intracranially

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy	tdcs	Healthy adults - Participants will receive single session of tdcs after application

Primary Outcome Measures

Name	Time	Method
Brain corticobulbar excitability	Immediately after single conditioning the brain	Change of Brain corticobulbar excitability by motor evoked potentials

Secondary Outcome Measures

Name	Time	Method
Tongue pressure measurement-	Immediate after single conditioning the brain	Change of tongue pressure measurement by Intra oral pressure assessment
Electrophysiological responses of swallowing -	Immediate after single conditioning the brain	Change of Electrophysiological responses of swallowing - With the use of a laryngeal transducer, will measure the mylohyoid amplitude

Trial Locations

Locations (2)

Department of Rehabilitation Medicine Bucheon St Mary's Hospital, Catholic University of Korea, College of Medicine; 🇰🇷 Bucheon, Kyounggido, Korea, Republic of

Department of Rehabilitation Medicine; 🇰🇷 Bucheon, Bucheonshi, Korea, Republic of