Study of the clinical effects by the central supply method of the acetic acid-free dialytic fluid

Not Applicable

• Conditions: end-stage renal failure

• Registration Number: JPRN-UMIN000011765
• Lead Sponsor: ational Defense Medical College

Brief Summary

58th Congress of the Japanese Society for Dialysis therapy Acetic acid-free dialytic fluid accepted meaningful improvement of acidotic revision, a nourishment state and anemia. By the long usage of the acetic acid-free dialytic fluid, blood GSH/GSSG was improved significantly, and plasma homocysteine significantly decreased. Thus, an effect to prevent the serious complications in the chronic hemodialysis patient is expected.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2012-06-03
• Study Start: 2013-09-17
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Not provided

Exclusion Criteria

hemodialysis patients without any cancer or acute Inflammation

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
For a hemodialysis patient, we examine a 12-month clinical response of acetic acid-free dialytic fluid after use in acetic acid dialytic fluid for six months. Examination item are dialysis efficiency (Kt/V), a circulation change (mean blood pressure and the pulse), nourishment dialyzing are in a state (serum protein and albumin, nPCR), acidotic improvement effect (pH, HCO3-, BE).

Secondary Outcome Measures

Name	Time	Method
For a hemodialysis patient, we measure a 12-month oxidation stress marker of acetic acid-free dialytic fluid after use in acetic acid dialytic fluid for six months. Examination item are blood reduced glutathione/oxidized glutathione ratio and serum MDA-LDL.