Observational study to search for factors that exacerbate the progression and prevention of lifestyle-related diseases through temporal observation of the 75g oral glucose tolerance test, gut microbiota analysis, and metabolites analysis.
Not Applicable
Completed
- Conditions
- Metabolic syndrome, obesity, pre diabetes, insulin resistance
- Registration Number
- JPRN-UMIN000047289
- Lead Sponsor
- niversity of the Ryukyus.
- Brief Summary
A total of 178 subjects were recruited with 140 individuals (70 females and 70 males) able to provide all the required measurements and samples including anthropometric measurements, clinical and biochemical blood samples as well as stool samples.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 178
Inclusion Criteria
Not provided
Exclusion Criteria
1) severe renal dysfunction (eGFR < 30 ml/min/1.73 m2) 2) hepatic dysfunction (AST > 200 IU/L or ALT > 200 IU/L) 3) malignancy,pregnancy, 4) chronic diarrhea 5) severe illness requiring hospitalization and treatment
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To search for factors that worsen the progression of lifestyle-related diseases and protective factors through the 75g oral glucose tolerance test, gut microbiota analysis, metabolites analysis, and questionnaire survey observation over time, and to evaluate their significance as early diagnostic markers and predictive markers of pathological progression.
- Secondary Outcome Measures
Name Time Method