Preemtive effect of intra venus Diphenhydramin injection before induction of anesthesiaon on attenuating airway and cardiovasculare reflexes during extubation of the endotracheal tube in Orthognathic Surgery.

Phase 2

• Conditions: Condition 1: Pain after maxillofacial surgery. Condition 2: Pain and agitation after maxillofacial surgery.; Fractures of other specified skull and facial bones; Dentofacial functional abnormalities; S02.8; K07.5

• Registration Number: IRCT20130304012695N3
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 15 June 2020

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

All patients who are candidates for elective orthognathic surgery

Exclusion Criteria

Drug addiction
cardiac ischemia
renal and hepatic dysfunction
history of large prostate
history of postoperative vomiting
glaucoma

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Severity of postoperative pain. Timepoint: During extubation and 5, 15, 30 and 60 minutes after surgery. Method of measurement: Visual Analogue Scale.;Severity of postoperative agitation. Timepoint: During extubation and 5, 15, 30 and 60 minutes after surgery. Method of measurement: Ramsy sedation Scale.

Secondary Outcome Measures

Name	Time	Method
Hemodynamic changes. Timepoint: During extubation and 5, 15, 30 and 60 minutes after surgery. Method of measurement: blood pressure and Heart Rate.