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Clinical Trials/JPRN-UMIN000007821
JPRN-UMIN000007821Completed未知

A Prospective Study of Diagnosis and Therapeutics in Intraocular Malignant Lymphoma - A Prospective Study of Diagnosis and Therapeutics in Intraocular Malignant Lymphoma

Deportment of Ophthalmology, University of Tokyo Hospital0 sites17 target enrollmentStarted: April 23, 2012Last updated:
Conditions

Trial Snapshot

Phase
未知
Status
Completed
Sponsor
Enrollment
17

Study Overview

Brief Summary

17 patients initiated and 16 completed the treatment. CNS relapse occurred in 2 and intraocular relapse in 3. 4-year PFS was 74.9% and 4-year OS was 86.3%. Of 11 patients without CNS involvement, 1 had CNS relapse and 3 intraocular relapse, and 4-year PFS was 72.7% and 4-year OS was 88.9%. No patients developed dementia/leukoencephalopathy. The combination of intravitreal chemotherapy, systemic chemotherapy and rdWBRT for B-cell PIOL showed a potential to reduce CNS relapse and improved 4-year PFS and OS.

Study Design

Study Type
Interventional

Eligibility Criteria

Ages
20years-old to 80years-old (—)
Sex
All

Inclusion Criteria

  • Not provided

Exclusion Criteria

  • Except for performance status 4

Investigators

Sponsor
Deportment of Ophthalmology, University of Tokyo Hospital

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