JPRN-UMIN000007821Completed未知
A Prospective Study of Diagnosis and Therapeutics in Intraocular Malignant Lymphoma - A Prospective Study of Diagnosis and Therapeutics in Intraocular Malignant Lymphoma
Deportment of Ophthalmology, University of Tokyo Hospital0 sites17 target enrollmentStarted: April 23, 2012Last updated:
Conditions
Trial Snapshot
- Phase
- 未知
- Status
- Completed
- Sponsor
- Enrollment
- 17
Study Overview
Brief Summary
17 patients initiated and 16 completed the treatment. CNS relapse occurred in 2 and intraocular relapse in 3. 4-year PFS was 74.9% and 4-year OS was 86.3%. Of 11 patients without CNS involvement, 1 had CNS relapse and 3 intraocular relapse, and 4-year PFS was 72.7% and 4-year OS was 88.9%. No patients developed dementia/leukoencephalopathy. The combination of intravitreal chemotherapy, systemic chemotherapy and rdWBRT for B-cell PIOL showed a potential to reduce CNS relapse and improved 4-year PFS and OS.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 20years-old to 80years-old (—)
- Sex
- All
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Except for performance status 4
Investigators
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