Effects of Hydrogen-Rich Water on Resting Metabolism in Healthy Young Adults: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 24
- 主要终点
- Resting Energy Expenditure (REE)
研究概览
简要总结
The H2REST trial is a randomized, double-blind, placebo-controlled crossover study investigating the acute effects of a single dose of hydrogen-rich water (HRW) on resting metabolism in healthy young adults. Participants complete two testing sessions-receiving either HRW or placebo in a randomized order-followed by standardized metabolic testing. Primary outcomes include resting energy expenditure, respiratory exchange ratio, and substrate utilization measured via indirect calorimetry. The study aims to assess whether acute HRW intake can modulate metabolic rate and fuel preference at rest, and to explore inter-individual variability in response.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 18-35 years
- •BMI between 18.5 and 25.0 kg/m²
- •Apparently healthy, with no history of chronic disease
- •Non-smoker, not currently using nicotine-containing products
- •Able to provide informed consent
- •Willing to refrain from alcohol, caffeine, and strenuous exercise for 24 hours before each study visit
- •Able to comply with study procedures, including fasting and attending all study visits
排除标准
- •Diagnosed metabolic, cardiovascular, respiratory, gastrointestinal, or endocrine disorders
- •Use of dietary supplements or medications affecting metabolism (within the past 2 weeks)
- •Allergy or intolerance to components of the hydrogen or placebo beverages
- •Pregnant or lactating
- •Shift work or irregular sleep schedule
- •Participation in another clinical study within the past 30 days
研究组 & 干预措施
ARM 2: 250 ml of Placebo Water (Non-hydrogen-producing tablets)
Non-hydrogen-producing tablets, identical in appearance and taste to the active supplement
干预措施: Placebo Comparator (Dietary Supplement)
ARM1: 250 ml of Hydrogen Rich Water
Hydrogen-producing tablets: Tablets designed to dissolve in water and release molecular hydrogen gas, creating hydrogen-rich water that can be consumed to potentially provide antioxidant and anti-inflammatory benefits.
干预措施: Molecular Hydrogen (Dietary Supplement)
结局指标
主要结局
Resting Energy Expenditure (REE)
时间窗: Participants will attend three study visits, with each intervention separated by a 7-day washout period to minimize carry-over effects. During each visit, measurements will be conducted approximately 30-60 minutes post-intervention.
The measurements will be obtained during each study visit. Since this is an interventional study assessing the acute effects of molecular hydrogen, measurements will be collected three times: At baseline, without any intervention (pre-familiarization), After a single dose of molecular hydrogen, and After placebo administration. The period between each intervention will be seven days, serving as a washout period to prevent carry-over effects. All participants will be instructed to maintain their regular diet and to avoid alcohol, caffeine-containing beverages, and strenuous physical activity for at least 24 hours prior to each visit. Measure Type: Continuous (kcal/day) Method: Indirect calorimetry Description: To assess the effect of acute ingestion of hydrogen-rich water versus placebo on resting energy expenditure in healthy young adults.
次要结局
未报告次要终点
研究者
Nikola Todorovic
Teaching assistant, PhD
University of Novi Sad