Palbociclib and FES PET

Phase 2

Completed

• Conditions: Breast Cancer
• Interventions: Drug: Palbociclib; Device: FES PET; Drug: Letrozole

• Registration Number: NCT02806050
• Lead Sponsor: University Medical Center Groningen

Brief Summary

The purpose is to evaluate whether non invasive in vivo imaging of the estrogen receptor (ER) presence in metastatic breast cancer patient by means of 18F-fluoro-estradiol (FES) positron emission tomography (PET) can be used to predict treatment response to palbociclib plus letrozole. As ER expression predicts response to palbociclib in metastatic breast cancer patients the investigators hypothesize that lesions with low uptake on FES-PET will not respond to the combination of letrozole plus palbociclib.

Detailed Description

To evaluate in a feasibility study whether low uptake on FES-PET at baseline is related to non response to letrozole plus palbociclib treatment. The investigators will perform this feasibility study in 15 patients with metastatic breast cancer, eligible for letrozole and palbociclib therapy.

All patients will be treated with letrozole 2.5mg daily continuously throughout a 28-day cycle. This is combined with palbociclib 125 mg daily for 21 consecutive days followed by 7 days off treatment. At baseline all patients will have a FES PET scan. Currently the combination with palbociclib and letrozole has been approved by the FDA as initial endocrine-based therapy for postmenopausal women with ER positive HER2 negative advanced breast cancer. This is based on improved progression free survival with 10 months compared to endocrine therapy alone in both first and second line hormonal treatment for ER-positive metastatic breast cancer. In Europe, approval is expected late 2016. Therefore, in this study, all patients will receive a (presumably effective) treatment combination, that patients do not have standard access to in the Netherlands yet. In addition to the standard control visits to the clinic, two extra visits will be performed as part of the study: for screening and for the FES-PET scan. In the future, this study may potentially contribute to improved selection of patients for this combination treatment. This is of relevance in view of optimal treatment for individual patients, avoiding unnecessary toxicity and financial burden.

Study Timeline

• Study First Submitted: 2016-05-17
• Study First Submitted QC: 2016-06-17
• Study First Posted: 2016-06-20
• Study Start: 2016-09-16
• Primary Completion: 2022-09-28
• Study Completion: 2022-09-28
• Status Verified: 2022-10
• Last Update Submitted: 2022-10-11
• Last Update Posted: 2022-10-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all of the following criteria:

1. Patients with ER positive (i.e. >1% staining), HER2 negative metastatic breast cancer (preferably assessment on fresh metastasis biopsy, alternatively archival metastasis biopsy)

2. Post-menopausal status defined as:

   • Age ≥60 years
   • Previous bilateral oophorectomy
   • Age <60 years and amenorrhea for >12 months in the absence of interfering hormonal therapies (such as LH-RH agonists and ER-antagonists
   • Age <60 years using ER antagonists should have amenorrhea for >12 months and FSH >24U/L and LH>14U/L

3. Adequate bone marrow and organ function defined as follows:

   • Absolute neutrophil count > 1.5 x 109/L
   • Platelet count >100 x 109/L
   • White blood cell count >3 x 109/L
   • AST and ALT <3.0 x upper limit of normal (ULN) or <5 xULN in case of known liver metastases.
   • Alkaline phosphatase <2.5 x ULN
   • Total serum bilirubin < ULN or total bilirubin <3.0 x ULN with direct bilirubin within normal range in patients with Gilbert's Syndrome
   • Creatinine clearance >50mL/min
   • Lipase/amylase <1/5 x ULN
   • Prothrombin time, partial thromboplastin time and INR <1.5 x ULN

4. ECOG performance 0-2

5. Signed written informed consent

6. Able to comply with the protocol

7. Age ≥18 years

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study:

1. Life expectancy < 3 months
2. Evidence of central nervous system metastases
3. Presence of life-threatening visceral metastases
4. Prior use of CDK4/6 inhibitor
5. Use of estrogen receptor ligands including estrogens, fulvestrant or tamoxifen <6 weeks before study entry.
6. Use of other anticancer therapy < 2 weeks prior to start with palbociclib
7. Concurrent malignancy
8. Active cardiac disease or a history of cardiac dysfunction
9. Patient is currently receiving any of the following medications and cannot be discontinued 7 days prior to the start of treatment that are known strong inducers or inhibitors of CYP3A4/5, known risk to prolong the QT interval or induce Torsades de Pointes, or narrow therapeutic window and are predominantly metabolized through CYP3A4/5.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Palbociclib and FES PET	Palbociclib	To evaluate whether low uptake on FES-PET at baseline is related to non-response to letrozole plus palbociclib treatment.
Palbociclib and FES PET	FES PET	To evaluate whether low uptake on FES-PET at baseline is related to non-response to letrozole plus palbociclib treatment.
Palbociclib and FES PET	Letrozole	To evaluate whether low uptake on FES-PET at baseline is related to non-response to letrozole plus palbociclib treatment.

Primary Outcome Measures

Name	Time	Method
The relation between low uptake on FES-PET to response per lesion	8 weeks after start of treatment

Secondary Outcome Measures

Name	Time	Method
quantitative FES-uptake and correlation with progression free survival	6 months
analysis of circulating tumor DNA and correlation with FES-PET results and progression free survival	6 months

Trial Locations

Locations (1)

University Medical Center Groningen; 🇳🇱 Groningen, Netherlands