Toxicities and survival outcomes of proton beam craniospinal irradiation (P-CSI) for pediatric brain tumor

• Conditions: Proton therapy, CSI, pediatric brain tumor, radiation, radiotherapy; Proton therapy in pediatric brain tumor

• Registration Number: TCTR20210810001
• Lead Sponsor: Ratchadapiseksompotch Fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-08-10
• Study Completion: 2024-03-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

1.Thai children
2.Diagnosed with pediatric brain tumor as follows.
Embryonal tumor, Medulloblastoma, PNET, ATRT, Pineoblastoma, Ependymoma with intracranial or spinal metastasis, Pure germ cell tumor with intracranial or spinal metastasis, Nongerminomatous germ cell tumor
3. ECOG 0,1,2
4.Receive proton CSI at King Chulalongkorn Memorial Hospital in September 2021 to March 2024

Exclusion Criteria

1.Did not receive maximal safe resection prior to radiation for embryonal tumor and ependymoma.
2. No MRI spine images
3.No CSF cytology report
4. Unable to have follow up visits at King Chulalongkorn Memorial hospital
5. Unable to have sedation during radiation course for non-cooperate patients

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Toxicitiy During CSI CTCAE score

Secondary Outcome Measures

Name	Time	Method
Oncological outcome 3 years after CSI Patients' status death, alive, disease free, recurrence