To Compare Intravenous and Oral Hydration of the Prevention for CIN in Elderly Patients Undergoing Intravenous CECT

Not Applicable

• Conditions: CIN
• Interventions: Procedure: enhanced computed tomography

• Registration Number: NCT03872739
• Lead Sponsor: Yu Danqing

Brief Summary

To Compare Intravenous and Oral Hydration of the Prevention for Contrast-induced Nephropathy in Elderly Patients Undergoing Intravenous Contrast-enhanced Computed Tomography.

Detailed Description

The prospective multicenter randomized controlled clinical research discusses the comparison of oral and intravenous hydration for prevention of contrast-induced nephropathy in elderly patients with enhanced computed tomography, establishing a simple hydration proposal.

Study Timeline

• Study Start: 2016-10-08
• Study First Submitted: 2019-02-27
• Status Verified: 2019-03
• Study First Submitted QC: 2019-03-10
• Last Update Submitted: 2019-03-10
• Study First Posted: 2019-03-13
• Last Update Posted: 2019-03-13
• Primary Completion: 2021-06-30
• Study Completion: 2021-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1368

Inclusion Criteria

• Age>21
• informed consent
• Undergoing Intravenous Contrast-enhanced Computed Tomography

Exclusion Criteria

• CT enhancement was not performed;
• Dialysis treatment of patients with end-stage renal failure or heart, kidney transplantation;
• Exposure to radioactive contrast medium within 48 hours prior to or within 72 hours of examination;
• Acute decompensated heart failure;
• Allergic to radioactive contrast agent;
• Be subjected to life - threatening trauma;
• Severe infection;
• Surgery was performed within 2 days of CT examination.
• Combined with multiple myeloma, urinary obstruction, aortic dissection
• Can cause acute kidney injury disease;
• Use of aminoglycosides and other nephrotoxic drugs 2 weeks before.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Saline	enhanced computed tomography	intravenous saline hydration at the rate of 1 mL/kg/h rate during undergoing enhanced computed tomography examination before and after 12 hours
distilled water	enhanced computed tomography	Oral distilled water at the rate of 3 mL/kg/h rate during undergoing enhanced computed tomography examination before 1-2 and after 4-6 hours

Primary Outcome Measures

Name	Time	Method
CIN	72hours	Compared with before examination, the increase of serum creatinine conforms to the diagnostic criteria of contrast induced nephropathy.

Trial Locations

Locations (1)

Guangdong provincial people's hospital; 🇨🇳 Guanzhou, Guangdong, China